The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas

Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are “endowed” with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcino...

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Autores principales: El Habr, Elias A., Adamopoulos, Christos, Levidou, Georgia, Saetta, Aggeliki A., Korkolopoulou, Penelope, Piperi, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316974/
https://www.ncbi.nlm.nih.gov/pubmed/22530122
http://dx.doi.org/10.1155/2012/454957
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author El Habr, Elias A.
Adamopoulos, Christos
Levidou, Georgia
Saetta, Aggeliki A.
Korkolopoulou, Penelope
Piperi, Christina
author_facet El Habr, Elias A.
Adamopoulos, Christos
Levidou, Georgia
Saetta, Aggeliki A.
Korkolopoulou, Penelope
Piperi, Christina
author_sort El Habr, Elias A.
collection PubMed
description Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are “endowed” with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors.
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spelling pubmed-33169742012-04-23 The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas El Habr, Elias A. Adamopoulos, Christos Levidou, Georgia Saetta, Aggeliki A. Korkolopoulou, Penelope Piperi, Christina Neurol Res Int Review Article Astrocytomas, the most common type of gliomas, and especially grade IV glioblastomas are “endowed” with strong proliferation and invasion potentials, high recurrence rate, and poor patients' prognosis. Aberrant signaling of AKT-mTOR (mammalian target of rapamycin) has been implicated in carcinogenesis. This paper is focused on the impact of deregulated AKT-mTOR signaling components in the clinical outcome and prognosis of human astrocytomas. Current therapeutic targeting of astrocytomas with AKT-mTOR inhibitors in preclinical and clinical stage is also discussed, including future perspectives regarding the management of these devastating tumors. Hindawi Publishing Corporation 2012 2012-02-21 /pmc/articles/PMC3316974/ /pubmed/22530122 http://dx.doi.org/10.1155/2012/454957 Text en Copyright © 2012 Elias A. El Habr et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
El Habr, Elias A.
Adamopoulos, Christos
Levidou, Georgia
Saetta, Aggeliki A.
Korkolopoulou, Penelope
Piperi, Christina
The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
title The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
title_full The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
title_fullStr The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
title_full_unstemmed The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
title_short The Clinical and Prognostic Significance of Activated AKT-mTOR Pathway in Human Astrocytomas
title_sort clinical and prognostic significance of activated akt-mtor pathway in human astrocytomas
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316974/
https://www.ncbi.nlm.nih.gov/pubmed/22530122
http://dx.doi.org/10.1155/2012/454957
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