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The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema

The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by high-resolution computed tomography (HRCT) of the chest, the deg...

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Autores principales: Chiba, Shigeki, Ohta, Hiromitsu, Abe, Kyoko, Hisata, Shu, Ohkouchi, Shinya, Hoshikawa, Yasushi, Kondo, Takashi, Ebina, Masahito
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316999/
https://www.ncbi.nlm.nih.gov/pubmed/22530118
http://dx.doi.org/10.1155/2012/492960
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author Chiba, Shigeki
Ohta, Hiromitsu
Abe, Kyoko
Hisata, Shu
Ohkouchi, Shinya
Hoshikawa, Yasushi
Kondo, Takashi
Ebina, Masahito
author_facet Chiba, Shigeki
Ohta, Hiromitsu
Abe, Kyoko
Hisata, Shu
Ohkouchi, Shinya
Hoshikawa, Yasushi
Kondo, Takashi
Ebina, Masahito
author_sort Chiba, Shigeki
collection PubMed
description The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by high-resolution computed tomography (HRCT) of the chest, the degree of progressive fibrosis, which increases with emphysematous lesions, is difficult to evaluate. In this study, we hypothesized that the biomarkers for pulmonary fibrosis, surfactant protein D (SP-D), and KL-6 would serve as good indicators of fibrotic lesions in CPFE. We recruited 46 patients who had been diagnosed in our hospital with both emphysema and fibrosis by their CT scan image from April 2003 to March 2008. The correlation among their pulmonary function tests, composite physiologic index (CPI), and the serum levels of SP-D and KL-6 was evaluated. We found a correlation between KL-6 and %VC, %TLC, or CPI and between SP-D and %VC or CPI. Interestingly, the combined product of KL-6 and SP-D (KL-6xSP-D) was found to highly correlate with %VC and %TLC or CPI. These results show that both KL-6 and SP-D, and especially the product of SP-D and KL-6, are good indicators of the presence of fibrotic lesions in the lungs of CPFE patients.
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spelling pubmed-33169992012-04-23 The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema Chiba, Shigeki Ohta, Hiromitsu Abe, Kyoko Hisata, Shu Ohkouchi, Shinya Hoshikawa, Yasushi Kondo, Takashi Ebina, Masahito Pulm Med Research Article The combined pulmonary fibrosis and emphysema (CPFE) was reported first in 1990, but it has been comparatively underestimated until recently. Although the diagnostic findings of both emphysematous and fibrotic regions are detectable by high-resolution computed tomography (HRCT) of the chest, the degree of progressive fibrosis, which increases with emphysematous lesions, is difficult to evaluate. In this study, we hypothesized that the biomarkers for pulmonary fibrosis, surfactant protein D (SP-D), and KL-6 would serve as good indicators of fibrotic lesions in CPFE. We recruited 46 patients who had been diagnosed in our hospital with both emphysema and fibrosis by their CT scan image from April 2003 to March 2008. The correlation among their pulmonary function tests, composite physiologic index (CPI), and the serum levels of SP-D and KL-6 was evaluated. We found a correlation between KL-6 and %VC, %TLC, or CPI and between SP-D and %VC or CPI. Interestingly, the combined product of KL-6 and SP-D (KL-6xSP-D) was found to highly correlate with %VC and %TLC or CPI. These results show that both KL-6 and SP-D, and especially the product of SP-D and KL-6, are good indicators of the presence of fibrotic lesions in the lungs of CPFE patients. Hindawi Publishing Corporation 2012 2012-02-28 /pmc/articles/PMC3316999/ /pubmed/22530118 http://dx.doi.org/10.1155/2012/492960 Text en Copyright © 2012 Shigeki Chiba et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chiba, Shigeki
Ohta, Hiromitsu
Abe, Kyoko
Hisata, Shu
Ohkouchi, Shinya
Hoshikawa, Yasushi
Kondo, Takashi
Ebina, Masahito
The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema
title The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema
title_full The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema
title_fullStr The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema
title_full_unstemmed The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema
title_short The Diagnostic Value of the Interstitial Biomarkers KL-6 and SP-D for the Degree of Fibrosis in Combined Pulmonary Fibrosis and Emphysema
title_sort diagnostic value of the interstitial biomarkers kl-6 and sp-d for the degree of fibrosis in combined pulmonary fibrosis and emphysema
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3316999/
https://www.ncbi.nlm.nih.gov/pubmed/22530118
http://dx.doi.org/10.1155/2012/492960
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