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Integrin Signaling in Mammary Epithelial Cells and Breast Cancer
Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion and intracellular signaling. Advances in understanding the mammary epithelial cell hierarchy are converging with new developments that reveal how integrins regulate the normal mamma...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Scholarly Research Network
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317013/ https://www.ncbi.nlm.nih.gov/pubmed/22523705 http://dx.doi.org/10.5402/2012/493283 |
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author | Lambert, Arthur W. Ozturk, Sait Thiagalingam, Sam |
author_facet | Lambert, Arthur W. Ozturk, Sait Thiagalingam, Sam |
author_sort | Lambert, Arthur W. |
collection | PubMed |
description | Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion and intracellular signaling. Advances in understanding the mammary epithelial cell hierarchy are converging with new developments that reveal how integrins regulate the normal mammary gland. But in breast cancer, integrin signaling contributes to the development and progression of tumors. This paper highlights recent studies which examine the role of integrin signaling in mammary epithelial cells and their malignant counterparts. |
format | Online Article Text |
id | pubmed-3317013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-33170132012-04-20 Integrin Signaling in Mammary Epithelial Cells and Breast Cancer Lambert, Arthur W. Ozturk, Sait Thiagalingam, Sam ISRN Oncol Review Article Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion and intracellular signaling. Advances in understanding the mammary epithelial cell hierarchy are converging with new developments that reveal how integrins regulate the normal mammary gland. But in breast cancer, integrin signaling contributes to the development and progression of tumors. This paper highlights recent studies which examine the role of integrin signaling in mammary epithelial cells and their malignant counterparts. International Scholarly Research Network 2012-03-01 /pmc/articles/PMC3317013/ /pubmed/22523705 http://dx.doi.org/10.5402/2012/493283 Text en Copyright © 2012 Arthur W. Lambert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Lambert, Arthur W. Ozturk, Sait Thiagalingam, Sam Integrin Signaling in Mammary Epithelial Cells and Breast Cancer |
title | Integrin Signaling in Mammary Epithelial Cells and Breast Cancer |
title_full | Integrin Signaling in Mammary Epithelial Cells and Breast Cancer |
title_fullStr | Integrin Signaling in Mammary Epithelial Cells and Breast Cancer |
title_full_unstemmed | Integrin Signaling in Mammary Epithelial Cells and Breast Cancer |
title_short | Integrin Signaling in Mammary Epithelial Cells and Breast Cancer |
title_sort | integrin signaling in mammary epithelial cells and breast cancer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317013/ https://www.ncbi.nlm.nih.gov/pubmed/22523705 http://dx.doi.org/10.5402/2012/493283 |
work_keys_str_mv | AT lambertarthurw integrinsignalinginmammaryepithelialcellsandbreastcancer AT ozturksait integrinsignalinginmammaryepithelialcellsandbreastcancer AT thiagalingamsam integrinsignalinginmammaryepithelialcellsandbreastcancer |