Cargando…

Integrin Signaling in Mammary Epithelial Cells and Breast Cancer

Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion and intracellular signaling. Advances in understanding the mammary epithelial cell hierarchy are converging with new developments that reveal how integrins regulate the normal mamma...

Descripción completa

Detalles Bibliográficos
Autores principales: Lambert, Arthur W., Ozturk, Sait, Thiagalingam, Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317013/
https://www.ncbi.nlm.nih.gov/pubmed/22523705
http://dx.doi.org/10.5402/2012/493283
_version_ 1782228489138601984
author Lambert, Arthur W.
Ozturk, Sait
Thiagalingam, Sam
author_facet Lambert, Arthur W.
Ozturk, Sait
Thiagalingam, Sam
author_sort Lambert, Arthur W.
collection PubMed
description Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion and intracellular signaling. Advances in understanding the mammary epithelial cell hierarchy are converging with new developments that reveal how integrins regulate the normal mammary gland. But in breast cancer, integrin signaling contributes to the development and progression of tumors. This paper highlights recent studies which examine the role of integrin signaling in mammary epithelial cells and their malignant counterparts.
format Online
Article
Text
id pubmed-3317013
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher International Scholarly Research Network
record_format MEDLINE/PubMed
spelling pubmed-33170132012-04-20 Integrin Signaling in Mammary Epithelial Cells and Breast Cancer Lambert, Arthur W. Ozturk, Sait Thiagalingam, Sam ISRN Oncol Review Article Cells sense and respond to the extracellular matrix (ECM) by way of integrin receptors, which facilitate cell adhesion and intracellular signaling. Advances in understanding the mammary epithelial cell hierarchy are converging with new developments that reveal how integrins regulate the normal mammary gland. But in breast cancer, integrin signaling contributes to the development and progression of tumors. This paper highlights recent studies which examine the role of integrin signaling in mammary epithelial cells and their malignant counterparts. International Scholarly Research Network 2012-03-01 /pmc/articles/PMC3317013/ /pubmed/22523705 http://dx.doi.org/10.5402/2012/493283 Text en Copyright © 2012 Arthur W. Lambert et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lambert, Arthur W.
Ozturk, Sait
Thiagalingam, Sam
Integrin Signaling in Mammary Epithelial Cells and Breast Cancer
title Integrin Signaling in Mammary Epithelial Cells and Breast Cancer
title_full Integrin Signaling in Mammary Epithelial Cells and Breast Cancer
title_fullStr Integrin Signaling in Mammary Epithelial Cells and Breast Cancer
title_full_unstemmed Integrin Signaling in Mammary Epithelial Cells and Breast Cancer
title_short Integrin Signaling in Mammary Epithelial Cells and Breast Cancer
title_sort integrin signaling in mammary epithelial cells and breast cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317013/
https://www.ncbi.nlm.nih.gov/pubmed/22523705
http://dx.doi.org/10.5402/2012/493283
work_keys_str_mv AT lambertarthurw integrinsignalinginmammaryepithelialcellsandbreastcancer
AT ozturksait integrinsignalinginmammaryepithelialcellsandbreastcancer
AT thiagalingamsam integrinsignalinginmammaryepithelialcellsandbreastcancer