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Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
The present study examined the effect of nicotine, alone and in combination with various drugs that act on the CNS, on ambulatory activity, a behavioral index for locomotion, in ICR (CD-1) strain mice. Nicotine at 0.25–2 mg/kg acutely reduced ambulatory activity of ICR mice. The effect of nicotine w...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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International Scholarly Research Network
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317018/ https://www.ncbi.nlm.nih.gov/pubmed/22530136 http://dx.doi.org/10.5402/2012/170981 |
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author | Umezu, Toyoshi |
author_facet | Umezu, Toyoshi |
author_sort | Umezu, Toyoshi |
collection | PubMed |
description | The present study examined the effect of nicotine, alone and in combination with various drugs that act on the CNS, on ambulatory activity, a behavioral index for locomotion, in ICR (CD-1) strain mice. Nicotine at 0.25–2 mg/kg acutely reduced ambulatory activity of ICR mice. The effect of nicotine was similar to that of haloperidol and fluphenazine but distinct from that of bupropion and methylphenidate. ICR mice developed tolerance against the inhibitory effect of nicotine on ambulatory activity when nicotine was repeatedly administered. This effect was also distinct from bupropion and methylphenidate as they produced augmentation of their ambulation-stimulating effects in ICR mice. Nicotine reduced the ambulation-stimulating effects of bupropion and methylphenidate as well as haloperidol and fluphenazine. Taken together, nicotine exhibited unusual effects as a psychostimulant on ambulatory activity in ICR mice. |
format | Online Article Text |
id | pubmed-3317018 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | International Scholarly Research Network |
record_format | MEDLINE/PubMed |
spelling | pubmed-33170182012-04-23 Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice Umezu, Toyoshi ISRN Pharmacol Research Article The present study examined the effect of nicotine, alone and in combination with various drugs that act on the CNS, on ambulatory activity, a behavioral index for locomotion, in ICR (CD-1) strain mice. Nicotine at 0.25–2 mg/kg acutely reduced ambulatory activity of ICR mice. The effect of nicotine was similar to that of haloperidol and fluphenazine but distinct from that of bupropion and methylphenidate. ICR mice developed tolerance against the inhibitory effect of nicotine on ambulatory activity when nicotine was repeatedly administered. This effect was also distinct from bupropion and methylphenidate as they produced augmentation of their ambulation-stimulating effects in ICR mice. Nicotine reduced the ambulation-stimulating effects of bupropion and methylphenidate as well as haloperidol and fluphenazine. Taken together, nicotine exhibited unusual effects as a psychostimulant on ambulatory activity in ICR mice. International Scholarly Research Network 2012-03-20 /pmc/articles/PMC3317018/ /pubmed/22530136 http://dx.doi.org/10.5402/2012/170981 Text en Copyright © 2012 Toyoshi Umezu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Umezu, Toyoshi Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice |
title | Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice |
title_full | Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice |
title_fullStr | Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice |
title_full_unstemmed | Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice |
title_short | Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice |
title_sort | unusual effects of nicotine as a psychostimulant on ambulatory activity in mice |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317018/ https://www.ncbi.nlm.nih.gov/pubmed/22530136 http://dx.doi.org/10.5402/2012/170981 |
work_keys_str_mv | AT umezutoyoshi unusualeffectsofnicotineasapsychostimulantonambulatoryactivityinmice |