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Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice

The present study examined the effect of nicotine, alone and in combination with various drugs that act on the CNS, on ambulatory activity, a behavioral index for locomotion, in ICR (CD-1) strain mice. Nicotine at 0.25–2 mg/kg acutely reduced ambulatory activity of ICR mice. The effect of nicotine w...

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Detalles Bibliográficos
Autor principal: Umezu, Toyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317018/
https://www.ncbi.nlm.nih.gov/pubmed/22530136
http://dx.doi.org/10.5402/2012/170981
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author Umezu, Toyoshi
author_facet Umezu, Toyoshi
author_sort Umezu, Toyoshi
collection PubMed
description The present study examined the effect of nicotine, alone and in combination with various drugs that act on the CNS, on ambulatory activity, a behavioral index for locomotion, in ICR (CD-1) strain mice. Nicotine at 0.25–2 mg/kg acutely reduced ambulatory activity of ICR mice. The effect of nicotine was similar to that of haloperidol and fluphenazine but distinct from that of bupropion and methylphenidate. ICR mice developed tolerance against the inhibitory effect of nicotine on ambulatory activity when nicotine was repeatedly administered. This effect was also distinct from bupropion and methylphenidate as they produced augmentation of their ambulation-stimulating effects in ICR mice. Nicotine reduced the ambulation-stimulating effects of bupropion and methylphenidate as well as haloperidol and fluphenazine. Taken together, nicotine exhibited unusual effects as a psychostimulant on ambulatory activity in ICR mice.
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spelling pubmed-33170182012-04-23 Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice Umezu, Toyoshi ISRN Pharmacol Research Article The present study examined the effect of nicotine, alone and in combination with various drugs that act on the CNS, on ambulatory activity, a behavioral index for locomotion, in ICR (CD-1) strain mice. Nicotine at 0.25–2 mg/kg acutely reduced ambulatory activity of ICR mice. The effect of nicotine was similar to that of haloperidol and fluphenazine but distinct from that of bupropion and methylphenidate. ICR mice developed tolerance against the inhibitory effect of nicotine on ambulatory activity when nicotine was repeatedly administered. This effect was also distinct from bupropion and methylphenidate as they produced augmentation of their ambulation-stimulating effects in ICR mice. Nicotine reduced the ambulation-stimulating effects of bupropion and methylphenidate as well as haloperidol and fluphenazine. Taken together, nicotine exhibited unusual effects as a psychostimulant on ambulatory activity in ICR mice. International Scholarly Research Network 2012-03-20 /pmc/articles/PMC3317018/ /pubmed/22530136 http://dx.doi.org/10.5402/2012/170981 Text en Copyright © 2012 Toyoshi Umezu. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Umezu, Toyoshi
Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
title Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
title_full Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
title_fullStr Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
title_full_unstemmed Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
title_short Unusual Effects of Nicotine as a Psychostimulant on Ambulatory Activity in Mice
title_sort unusual effects of nicotine as a psychostimulant on ambulatory activity in mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317018/
https://www.ncbi.nlm.nih.gov/pubmed/22530136
http://dx.doi.org/10.5402/2012/170981
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