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Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma
Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker in predicting pulmonary complications (PC) in m...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317019/ https://www.ncbi.nlm.nih.gov/pubmed/22529525 http://dx.doi.org/10.1155/2012/536156 |
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author | Auner, Birgit Geiger, Emanuel V. Henrich, Dirk Lehnert, Mark Marzi, Ingo Relja, Borna |
author_facet | Auner, Birgit Geiger, Emanuel V. Henrich, Dirk Lehnert, Mark Marzi, Ingo Relja, Borna |
author_sort | Auner, Birgit |
collection | PubMed |
description | Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker in predicting pulmonary complications (PC) in multiply traumatized patients. Methods: Plasma levels of LTB4 were determined in 100 patients on admission (ED) and for five consecutive days (daily). Twenty healthy volunteers served as control. LTB4-levels were measured by ELISA. Thirty patients developed PC (pneumonia, respiratory failure, acute lung injury (ALI), ARDS, pulmonary embolism) and 70 had no PC (ØPC). Results. LTB4-levels in the PC-group [127.8 pg/mL, IQR: 104–200pg/ml] were significantly higher compared to the ØPC-group on admission [95.6 pg/mL, IQR: 55–143 pg/mL] or control-group [58.4 pg/mL, IQR: 36–108 pg/mL]. LTB4 continuously declined to basal levels from day 1 to 5 without differences between the groups. The cutoff to predict PC was calculated at 109.6 pg/mL (72% specificity, 67% sensitivity). LTB4 was not influenced by overall or chest injury severity, age, gender or massive transfusion. Patients with PC received mechanical ventilation for a significantly longer period of time, and had prolonged intensive care unit and overall hospital stay. Conclusion. High LTB4-levels indicate risk for PC development in multiply traumatized patients. |
format | Online Article Text |
id | pubmed-3317019 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33170192012-04-23 Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma Auner, Birgit Geiger, Emanuel V. Henrich, Dirk Lehnert, Mark Marzi, Ingo Relja, Borna Mediators Inflamm Clinical Study Background. Leukotriene B4 (LTB4), a proinflammatory lipid mediator correlates well with the acute phase of Acute Respiratory Distress Syndrome (ARDS). Therefore, LTB4-levels were investigated to determine whether they might be a useful clinical marker in predicting pulmonary complications (PC) in multiply traumatized patients. Methods: Plasma levels of LTB4 were determined in 100 patients on admission (ED) and for five consecutive days (daily). Twenty healthy volunteers served as control. LTB4-levels were measured by ELISA. Thirty patients developed PC (pneumonia, respiratory failure, acute lung injury (ALI), ARDS, pulmonary embolism) and 70 had no PC (ØPC). Results. LTB4-levels in the PC-group [127.8 pg/mL, IQR: 104–200pg/ml] were significantly higher compared to the ØPC-group on admission [95.6 pg/mL, IQR: 55–143 pg/mL] or control-group [58.4 pg/mL, IQR: 36–108 pg/mL]. LTB4 continuously declined to basal levels from day 1 to 5 without differences between the groups. The cutoff to predict PC was calculated at 109.6 pg/mL (72% specificity, 67% sensitivity). LTB4 was not influenced by overall or chest injury severity, age, gender or massive transfusion. Patients with PC received mechanical ventilation for a significantly longer period of time, and had prolonged intensive care unit and overall hospital stay. Conclusion. High LTB4-levels indicate risk for PC development in multiply traumatized patients. Hindawi Publishing Corporation 2012 2012-03-07 /pmc/articles/PMC3317019/ /pubmed/22529525 http://dx.doi.org/10.1155/2012/536156 Text en Copyright © 2012 Birgit Auner et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Clinical Study Auner, Birgit Geiger, Emanuel V. Henrich, Dirk Lehnert, Mark Marzi, Ingo Relja, Borna Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma |
title | Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma |
title_full | Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma |
title_fullStr | Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma |
title_full_unstemmed | Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma |
title_short | Circulating Leukotriene B4 Identifies Respiratory Complications after Trauma |
title_sort | circulating leukotriene b4 identifies respiratory complications after trauma |
topic | Clinical Study |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317019/ https://www.ncbi.nlm.nih.gov/pubmed/22529525 http://dx.doi.org/10.1155/2012/536156 |
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