Cargando…

A New Experimental Polytrauma Model in Rats: Molecular Characterization of the Early Inflammatory Response

Background. The molecular mechanisms of the immune response after polytrauma are highly complex and far from fully understood. In this paper, we characterize a new standardized polytrauma model in rats based on the early molecular inflammatory and apoptotic response. Methods. Male Wistar rats (250 g...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weckbach, Sebastian, Perl, Mario, Heiland, Tim, Braumüller, Sonja, Stahel, Philip F., Flierl, Michael A., Ignatius, Anita, Gebhard, Florian, Huber-Lang, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317068/ https://www.ncbi.nlm.nih.gov/pubmed/22481866 http://dx.doi.org/10.1155/2012/890816

Ejemplares similares

Complement Factor C5a Inhibits Apoptosis of Neutrophils—A Mechanism in Polytrauma?
por: Ehrnthaller, Christian, et al.
Publicado: (2021)

Early structural changes of the heart after experimental polytrauma and hemorrhagic shock
por: Braun, Christian K., et al.
Publicado: (2017)

Early Detection of Junctional Adhesion Molecule-1 (JAM-1) in the Circulation after Experimental and Clinical Polytrauma
por: Denk, Stephanie, et al.
Publicado: (2015)

Role of the C5a-C5a receptor axis in the inflammatory responses of the lungs after experimental polytrauma and hemorrhagic shock
por: Chakraborty, Shinjini, et al.
Publicado: (2021)

Disturbances of the hypothalamic-pituitary-adrenal axis and plasma electrolytes during experimental sepsis
por: Flierl, Michael A, et al.
Publicado: (2011)

New Insights into the Role of Peroxisome Proliferator-Activated Receptors in Regulating the Inflammatory Response after Tissue Injury
por: Neher, Miriam D., et al.
Publicado: (2012)

Molecular mechanisms of inflammation and tissue injury after major trauma-is complement the "bad guy"?
por: Neher, Miriam D, et al.
Publicado: (2011)

Toll-Like Receptor-Mediated Cardiac Injury during Experimental Sepsis
por: Lackner, Ina, et al.
Publicado: (2020)

Editorial: The impact of COVID-19 on immune system-related complications in surgical patients
por: Stahel, Philip F., et al.
Publicado: (2023)

Role of Complement C5 in Experimental Blunt Chest Trauma-Induced Septic Acute Lung Injury (ALI)
por: Kalbitz, Miriam, et al.
Publicado: (2016)

The molecular fingerprint of lung inflammation after blunt chest trauma
por: Ehrnthaller, Christian, et al.
Publicado: (2015)

New Insights of an Old Defense System: Structure, Function, and Clinical Relevance of the Complement System
por: Ehrnthaller, Christian, et al.
Publicado: (2011)

C5aR inhibition in the early inflammatory phase does not affect bone regeneration in a model of uneventful fracture healing
por: Ehrnthaller, Christian, et al.
Publicado: (2016)

The Prognostic Value of Troponin in Pediatric Polytrauma
por: Braun, Christian Karl, et al.
Publicado: (2019)

Inflammatory Changes and Coagulopathy in Multiply Injured Patients
por: Huber-Lang, Markus, et al.
Publicado: (2015)

Patient Safety in Surgery: practical tips for authors to circumvent the journal’s high rejection rate
por: Stahel, Philip F., et al.
Publicado: (2020)

Mesenchymal Stem Cells after Polytrauma: Actor and Target
por: Huber-Lang, Markus, et al.
Publicado: (2016)

Advocating "spine damage control" as a safe and effective treatment modality for unstable thoracolumbar fractures in polytrauma patients: a hypothesis
por: Stahel, Philip F, et al.
Publicado: (2009)

Evaluation of the gut microbiome in association with biological signatures of inflammation in murine polytrauma and shock
por: Appiah, Sandra A., et al.
Publicado: (2021)

Pathophysiology of septic encephalopathy - an unsolved puzzle
por: Flierl, Michael A, et al.
Publicado: (2010)

Complement in Human Disease
por: Flierl, Michael A., et al.
Publicado: (2013)

Survival following a vertical free fall from 300 feet: The crucial role of body position to impact surface
por: Weckbach, Sebastian, et al.
Publicado: (2011)

Metabolic changes after polytrauma: an imperative for early nutritional support
por: Hasenboehler, Erik, et al.
Publicado: (2006)

Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction
por: Karasu, Ebru, et al.
Publicado: (2019)

Inflammatory response of mesenchymal stromal cells after in vivo exposure with selected trauma-related factors and polytrauma serum
por: Amann, Elisa Maria, et al.
Publicado: (2019)

Corrigendum: Targeting Complement Pathways in Polytrauma- and Sepsis-Induced Multiple-Organ Dysfunction
por: Karasu, Ebru, et al.
Publicado: (2019)

Crucial Role of IL1beta and C3a in the In Vitro-Response of Multipotent Mesenchymal Stromal Cells to Inflammatory Mediators of Polytrauma
por: Hengartner, Nina-Emily, et al.
Publicado: (2015)

Laboratory Markers in the Management of Pediatric Polytrauma: Current Role and Areas of Future Research
por: Weber, Birte, et al.
Publicado: (2021)

Polytrauma
por: Guerado, Enrique
Publicado: (2015)

Hemorrhagic Shock Induces a Rapid Transcriptomic Shift of the Immune Balance in Leukocytes after Experimental Multiple Injury
por: Debler, Lisa, et al.
Publicado: (2021)

MDSCs are induced after experimental blunt chest trauma and subsequently alter antigen-specific T cell responses
por: Hüsecken, Yvonne, et al.
Publicado: (2017)

The history of risk: a review
por: Stahel, Philip F., et al.
Publicado: (2017)

The immune response after fracture trauma is different in old compared to young patients
por: Vester, Helen, et al.
Publicado: (2014)

Polytrauma in the elderly: a review
por: Braun, Benedikt Johannes, et al.
Publicado: (2016)

Clinicopathogenetic aspects of systemic inflammatory response development in polytrauma
por: Ustyantseva, I, et al.
Publicado: (2010)

Systemic Inflammatory Effects of Traumatic Brain Injury, Femur Fracture, and Shock: An Experimental Murine Polytrauma Model
por: Probst, C., et al.
Publicado: (2012)

Introducing standardized “readbacks” to improve patient safety in surgery: a prospective survey in 92 providers at a public safety-net hospital
por: Prabhakar, Hari, et al.
Publicado: (2012)

Complement C3 and C5 Deficiency Affects Fracture Healing
por: Ehrnthaller, Christian, et al.
Publicado: (2013)

Influence of Menopause on Inflammatory Cytokines during Murine and Human Bone Fracture Healing
por: Fischer, Verena, et al.
Publicado: (2018)

Alteration of complement hemolytic activity in different trauma and sepsis models
por: Ehrnthaller, Christian, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_95e2upqk56g5opanju2kdehmls