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Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital

Introduction. Clinical presentation of viral hepatitis ranges from mild symptoms to fulminant hepatitis. Our aim is to describe clinical presentation and outcomes of children with viral hepatitis from the Eastern Ontario/Western Quebec regions of Canada. Methods. Retrospective chart review of childr...

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Autores principales: Cybulska, Paulina, Ni, Andy, Jimenez-Rivera, Carolina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317099/
https://www.ncbi.nlm.nih.gov/pubmed/22482064
http://dx.doi.org/10.5402/2011/182964
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author Cybulska, Paulina
Ni, Andy
Jimenez-Rivera, Carolina
author_facet Cybulska, Paulina
Ni, Andy
Jimenez-Rivera, Carolina
author_sort Cybulska, Paulina
collection PubMed
description Introduction. Clinical presentation of viral hepatitis ranges from mild symptoms to fulminant hepatitis. Our aim is to describe clinical presentation and outcomes of children with viral hepatitis from the Eastern Ontario/Western Quebec regions of Canada. Methods. Retrospective chart review of children diagnosed with viral hepatitis at our institution from January 1, 1998, to December 31, 2007. Results. There were 261 charts reviewed, only 64 had a confirmed viral etiology: 34 (53%) hepatitis B (HBV), 16 (25%) hepatitis C (HCV), 4 (6.3%) hepatitis A (HAV), 7 (11%) cytomegalovirus (CMV), and 3 (4.7%) Epstein-Barr virus (EBV). Children with HBV presented at a mean age of 6.4 ± 4.6 years. Spontaneous seroconversion (appearance of HBVeAb and loss of HBVeAg) occurred in 21/34 (61.7%). Children with acute hepatitis (HAV, CMV, and EBV) presented with mild abdominal pain, jaundice, and fevers. Overall outcome was excellent. Conclusion. Acute and chronic hepatitis in children has a benign course; moreover, HBV spontaneous seroconversion is common in pediatric patients.
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spelling pubmed-33170992012-04-05 Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital Cybulska, Paulina Ni, Andy Jimenez-Rivera, Carolina ISRN Pediatr Research Article Introduction. Clinical presentation of viral hepatitis ranges from mild symptoms to fulminant hepatitis. Our aim is to describe clinical presentation and outcomes of children with viral hepatitis from the Eastern Ontario/Western Quebec regions of Canada. Methods. Retrospective chart review of children diagnosed with viral hepatitis at our institution from January 1, 1998, to December 31, 2007. Results. There were 261 charts reviewed, only 64 had a confirmed viral etiology: 34 (53%) hepatitis B (HBV), 16 (25%) hepatitis C (HCV), 4 (6.3%) hepatitis A (HAV), 7 (11%) cytomegalovirus (CMV), and 3 (4.7%) Epstein-Barr virus (EBV). Children with HBV presented at a mean age of 6.4 ± 4.6 years. Spontaneous seroconversion (appearance of HBVeAb and loss of HBVeAg) occurred in 21/34 (61.7%). Children with acute hepatitis (HAV, CMV, and EBV) presented with mild abdominal pain, jaundice, and fevers. Overall outcome was excellent. Conclusion. Acute and chronic hepatitis in children has a benign course; moreover, HBV spontaneous seroconversion is common in pediatric patients. International Scholarly Research Network 2011 2010-12-29 /pmc/articles/PMC3317099/ /pubmed/22482064 http://dx.doi.org/10.5402/2011/182964 Text en Copyright © 2011 Paulina Cybulska et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Cybulska, Paulina
Ni, Andy
Jimenez-Rivera, Carolina
Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital
title Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital
title_full Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital
title_fullStr Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital
title_full_unstemmed Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital
title_short Viral Hepatitis: Retrospective Review in a Canadian Pediatric Hospital
title_sort viral hepatitis: retrospective review in a canadian pediatric hospital
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317099/
https://www.ncbi.nlm.nih.gov/pubmed/22482064
http://dx.doi.org/10.5402/2011/182964
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