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Cytoskeleton as an Emerging Target of Anthrax Toxins
Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we p...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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MDPI
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317109/ https://www.ncbi.nlm.nih.gov/pubmed/22474568 http://dx.doi.org/10.3390/toxins4020083 |
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author | Trescos, Yannick Tournier, Jean-Nicolas |
author_facet | Trescos, Yannick Tournier, Jean-Nicolas |
author_sort | Trescos, Yannick |
collection | PubMed |
description | Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity. |
format | Online Article Text |
id | pubmed-3317109 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-33171092012-04-03 Cytoskeleton as an Emerging Target of Anthrax Toxins Trescos, Yannick Tournier, Jean-Nicolas Toxins (Basel) Review Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity. MDPI 2012-02-06 /pmc/articles/PMC3317109/ /pubmed/22474568 http://dx.doi.org/10.3390/toxins4020083 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Trescos, Yannick Tournier, Jean-Nicolas Cytoskeleton as an Emerging Target of Anthrax Toxins |
title | Cytoskeleton as an Emerging Target of Anthrax Toxins |
title_full | Cytoskeleton as an Emerging Target of Anthrax Toxins |
title_fullStr | Cytoskeleton as an Emerging Target of Anthrax Toxins |
title_full_unstemmed | Cytoskeleton as an Emerging Target of Anthrax Toxins |
title_short | Cytoskeleton as an Emerging Target of Anthrax Toxins |
title_sort | cytoskeleton as an emerging target of anthrax toxins |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317109/ https://www.ncbi.nlm.nih.gov/pubmed/22474568 http://dx.doi.org/10.3390/toxins4020083 |
work_keys_str_mv | AT trescosyannick cytoskeletonasanemergingtargetofanthraxtoxins AT tournierjeannicolas cytoskeletonasanemergingtargetofanthraxtoxins |