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Cytoskeleton as an Emerging Target of Anthrax Toxins

Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we p...

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Detalles Bibliográficos
Autores principales: Trescos, Yannick, Tournier, Jean-Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317109/
https://www.ncbi.nlm.nih.gov/pubmed/22474568
http://dx.doi.org/10.3390/toxins4020083
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author Trescos, Yannick
Tournier, Jean-Nicolas
author_facet Trescos, Yannick
Tournier, Jean-Nicolas
author_sort Trescos, Yannick
collection PubMed
description Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity.
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spelling pubmed-33171092012-04-03 Cytoskeleton as an Emerging Target of Anthrax Toxins Trescos, Yannick Tournier, Jean-Nicolas Toxins (Basel) Review Bacillus anthracis, the agent of anthrax, has gained virulence through its exotoxins produced by vegetative bacilli and is composed of three components forming lethal toxin (LT) and edema toxin (ET). So far, little is known about the effects of these toxins on the eukaryotic cytoskeleton. Here, we provide an overview on the general effects of toxin upon the cytoskeleton architecture. Thus, we shall discuss how anthrax toxins interact with their receptors and may disrupt the interface between extracellular matrix and the cytoskeleton. We then analyze what toxin molecular effects on cytoskeleton have been described, before discussing how the cytoskeleton may help the pathogen to corrupt general cell processes such as phagocytosis or vascular integrity. MDPI 2012-02-06 /pmc/articles/PMC3317109/ /pubmed/22474568 http://dx.doi.org/10.3390/toxins4020083 Text en © 2012 by the authors; licensee MDPI, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0/ This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Trescos, Yannick
Tournier, Jean-Nicolas
Cytoskeleton as an Emerging Target of Anthrax Toxins
title Cytoskeleton as an Emerging Target of Anthrax Toxins
title_full Cytoskeleton as an Emerging Target of Anthrax Toxins
title_fullStr Cytoskeleton as an Emerging Target of Anthrax Toxins
title_full_unstemmed Cytoskeleton as an Emerging Target of Anthrax Toxins
title_short Cytoskeleton as an Emerging Target of Anthrax Toxins
title_sort cytoskeleton as an emerging target of anthrax toxins
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317109/
https://www.ncbi.nlm.nih.gov/pubmed/22474568
http://dx.doi.org/10.3390/toxins4020083
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