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Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep

Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. Here, it is shown that bradykinin in the abomasum is positively correlated with both mast cells...

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Autor principal: Williams, Andrew R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317117/
https://www.ncbi.nlm.nih.gov/pubmed/22523641
http://dx.doi.org/10.1155/2012/569287
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author Williams, Andrew R.
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description Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. Here, it is shown that bradykinin in the abomasum is positively correlated with both mast cells and globule leukocytes in the abomasum, and that all three of these parameters are negatively associated with numbers of adult Teladorsagia circumcincta during the challenge of immune sheep. It is suggested that bradykinin either stimulates the degranulation of mast cells, or is released during this degranulation process, or both. Multiple regression showed that almost 60% of the variation of in adult T. circumcincta could be explained by two variables, bradykinin and T. circumcincta—specific IgG(1) in plasma. This provides further evidence that bradykinin may be a mechanism of protective immunity in sheep, although its involvement in asthma and other allergic disorders raises questions about its role in unwanted immunopathology.
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spelling pubmed-33171172012-04-20 Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep Williams, Andrew R. J Parasitol Res Research Article Bradykinin is a physiologically active peptide involved in vasodilation and smooth muscle contraction and is previously shown to be increased in gastrointestinal mucus during nematode challenge in sheep. Here, it is shown that bradykinin in the abomasum is positively correlated with both mast cells and globule leukocytes in the abomasum, and that all three of these parameters are negatively associated with numbers of adult Teladorsagia circumcincta during the challenge of immune sheep. It is suggested that bradykinin either stimulates the degranulation of mast cells, or is released during this degranulation process, or both. Multiple regression showed that almost 60% of the variation of in adult T. circumcincta could be explained by two variables, bradykinin and T. circumcincta—specific IgG(1) in plasma. This provides further evidence that bradykinin may be a mechanism of protective immunity in sheep, although its involvement in asthma and other allergic disorders raises questions about its role in unwanted immunopathology. Hindawi Publishing Corporation 2012 2012-02-23 /pmc/articles/PMC3317117/ /pubmed/22523641 http://dx.doi.org/10.1155/2012/569287 Text en Copyright © 2012 Andrew R. Williams. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Williams, Andrew R.
Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
title Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
title_full Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
title_fullStr Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
title_full_unstemmed Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
title_short Short Communication: Some Observations on the Role of Bradykinin in Immunity to Teladorsagia circumcincta in Sheep
title_sort short communication: some observations on the role of bradykinin in immunity to teladorsagia circumcincta in sheep
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317117/
https://www.ncbi.nlm.nih.gov/pubmed/22523641
http://dx.doi.org/10.1155/2012/569287
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