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The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors

Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by wh...

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Autores principales: Panariello, Fabio, Polsinelli, Gina, Borlido, Carol, Monda, Marcellino, De Luca, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317122/
https://www.ncbi.nlm.nih.gov/pubmed/22523667
http://dx.doi.org/10.1155/2012/572848
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author Panariello, Fabio
Polsinelli, Gina
Borlido, Carol
Monda, Marcellino
De Luca, Vincenzo
author_facet Panariello, Fabio
Polsinelli, Gina
Borlido, Carol
Monda, Marcellino
De Luca, Vincenzo
author_sort Panariello, Fabio
collection PubMed
description Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by which they increase weight and produce metabolic disturbances are unclear. Several lines of research indicate that leptin could be a good candidate involved in pathways linking antipsychotic treatment and weight gain. Leptin is a circulating hormone released by adipocytes in response to increased fat deposition to regulate body weight, acting through receptors in the hypothalamus. In this work, we reviewed preclinical, clinical, and genetic data in order to infer the potential role played by leptin in antipsychotic-induced weight gain considering two main hypotheses: (1) leptin is an epiphenomenon of weight gain; (2) leptin is a consequence of antipsychotic-induced “leptin-resistance status,” causing weight gain.
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spelling pubmed-33171222012-04-20 The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors Panariello, Fabio Polsinelli, Gina Borlido, Carol Monda, Marcellino De Luca, Vincenzo J Obes Review Article Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by which they increase weight and produce metabolic disturbances are unclear. Several lines of research indicate that leptin could be a good candidate involved in pathways linking antipsychotic treatment and weight gain. Leptin is a circulating hormone released by adipocytes in response to increased fat deposition to regulate body weight, acting through receptors in the hypothalamus. In this work, we reviewed preclinical, clinical, and genetic data in order to infer the potential role played by leptin in antipsychotic-induced weight gain considering two main hypotheses: (1) leptin is an epiphenomenon of weight gain; (2) leptin is a consequence of antipsychotic-induced “leptin-resistance status,” causing weight gain. Hindawi Publishing Corporation 2012 2012-03-07 /pmc/articles/PMC3317122/ /pubmed/22523667 http://dx.doi.org/10.1155/2012/572848 Text en Copyright © 2012 Fabio Panariello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Panariello, Fabio
Polsinelli, Gina
Borlido, Carol
Monda, Marcellino
De Luca, Vincenzo
The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors
title The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors
title_full The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors
title_fullStr The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors
title_full_unstemmed The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors
title_short The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors
title_sort role of leptin in antipsychotic-induced weight gain: genetic and non-genetic factors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317122/
https://www.ncbi.nlm.nih.gov/pubmed/22523667
http://dx.doi.org/10.1155/2012/572848
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