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The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors
Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by wh...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317122/ https://www.ncbi.nlm.nih.gov/pubmed/22523667 http://dx.doi.org/10.1155/2012/572848 |
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author | Panariello, Fabio Polsinelli, Gina Borlido, Carol Monda, Marcellino De Luca, Vincenzo |
author_facet | Panariello, Fabio Polsinelli, Gina Borlido, Carol Monda, Marcellino De Luca, Vincenzo |
author_sort | Panariello, Fabio |
collection | PubMed |
description | Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by which they increase weight and produce metabolic disturbances are unclear. Several lines of research indicate that leptin could be a good candidate involved in pathways linking antipsychotic treatment and weight gain. Leptin is a circulating hormone released by adipocytes in response to increased fat deposition to regulate body weight, acting through receptors in the hypothalamus. In this work, we reviewed preclinical, clinical, and genetic data in order to infer the potential role played by leptin in antipsychotic-induced weight gain considering two main hypotheses: (1) leptin is an epiphenomenon of weight gain; (2) leptin is a consequence of antipsychotic-induced “leptin-resistance status,” causing weight gain. |
format | Online Article Text |
id | pubmed-3317122 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33171222012-04-20 The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors Panariello, Fabio Polsinelli, Gina Borlido, Carol Monda, Marcellino De Luca, Vincenzo J Obes Review Article Schizophrenia is a chronic and disabling mental illness affecting millions of people worldwide. A greater proportion of people with schizophrenia tends to be overweight. Antipsychotic medications have been considered the primary risk factor for obesity in schizophrenia, although the mechanisms by which they increase weight and produce metabolic disturbances are unclear. Several lines of research indicate that leptin could be a good candidate involved in pathways linking antipsychotic treatment and weight gain. Leptin is a circulating hormone released by adipocytes in response to increased fat deposition to regulate body weight, acting through receptors in the hypothalamus. In this work, we reviewed preclinical, clinical, and genetic data in order to infer the potential role played by leptin in antipsychotic-induced weight gain considering two main hypotheses: (1) leptin is an epiphenomenon of weight gain; (2) leptin is a consequence of antipsychotic-induced “leptin-resistance status,” causing weight gain. Hindawi Publishing Corporation 2012 2012-03-07 /pmc/articles/PMC3317122/ /pubmed/22523667 http://dx.doi.org/10.1155/2012/572848 Text en Copyright © 2012 Fabio Panariello et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Panariello, Fabio Polsinelli, Gina Borlido, Carol Monda, Marcellino De Luca, Vincenzo The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
title | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
title_full | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
title_fullStr | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
title_full_unstemmed | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
title_short | The Role of Leptin in Antipsychotic-Induced Weight Gain: Genetic and Non-Genetic Factors |
title_sort | role of leptin in antipsychotic-induced weight gain: genetic and non-genetic factors |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317122/ https://www.ncbi.nlm.nih.gov/pubmed/22523667 http://dx.doi.org/10.1155/2012/572848 |
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