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Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population

Background. Metaboreflex overactivation has been proprosed to explain exaggerated hyperventilation in heart failure population. We investigated the metaboreflex activation after cardiac resynchronization therapy (CRT). Methods. 10 heart failure patients (mean left ventricular ejection fraction (LVEF...

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Autores principales: Jaussaud, Jérémie, Aimable, Laurie, Bordachar, Pierre, Dos Santos, Pierre, Barandon, Laurent, Ritter, Philippe, Roudaut, Raymond, Douard, Hervé
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317128/
https://www.ncbi.nlm.nih.gov/pubmed/22536532
http://dx.doi.org/10.1155/2012/914071
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author Jaussaud, Jérémie
Aimable, Laurie
Bordachar, Pierre
Dos Santos, Pierre
Barandon, Laurent
Ritter, Philippe
Roudaut, Raymond
Douard, Hervé
author_facet Jaussaud, Jérémie
Aimable, Laurie
Bordachar, Pierre
Dos Santos, Pierre
Barandon, Laurent
Ritter, Philippe
Roudaut, Raymond
Douard, Hervé
author_sort Jaussaud, Jérémie
collection PubMed
description Background. Metaboreflex overactivation has been proprosed to explain exaggerated hyperventilation in heart failure population. We investigated the metaboreflex activation after cardiac resynchronization therapy (CRT). Methods. 10 heart failure patients (mean left ventricular ejection fraction (LVEF) 27 ± 4%) schedulded for CRT implantation were prospectively studied. At baseline and after 6 month follow up two maximal cardiopulmonary exercise tests with and without regional circulatory occlusion (RCO) during recovery were performed. RCO was achieved by inflation of bilateral upper thigh tourniquets 30 mmHg above peak systolic blood pressure during 3 minutes after peak exercise. Metaboreflex contribution to the ventilatory response was assessed as the difference in ventilatory data at the third minute during recovery between the two tests (Δ). Results. Patients had enhanced VE/VCO(2) slope (40 ± 9) and an evident metaboreflex contribution to the high ventilatory response (ΔVE: 3 ± 4 L/min; P = 0.05, ΔRR: 4.5 ± 4/min; P = 0.003 and ΔVE/VCO(2): 5.5 ± 4; P = 0.007). 6 months after CRT implantation, NYHA class, LVEF, peak VO(2) and VE/VCO(2) were significantly improved (1.4 ± 0.5; P < 0.001, 42 ± 7%; P < 0.001, 16.5 ± 3 mL/kg/min; P = 0.003; 33 ± 10; P = 0.01). Metaboreflex contribution to VE, RR, and VE/VCO(2) was reduced compared with baseline (P = 0.08, P = 0.01 and P = 0.4 resp.). Conclusion. 6 months after CRT metaboreflex contribution to the ventilatory response is reduced.
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spelling pubmed-33171282012-04-25 Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population Jaussaud, Jérémie Aimable, Laurie Bordachar, Pierre Dos Santos, Pierre Barandon, Laurent Ritter, Philippe Roudaut, Raymond Douard, Hervé Cardiol Res Pract Clinical Study Background. Metaboreflex overactivation has been proprosed to explain exaggerated hyperventilation in heart failure population. We investigated the metaboreflex activation after cardiac resynchronization therapy (CRT). Methods. 10 heart failure patients (mean left ventricular ejection fraction (LVEF) 27 ± 4%) schedulded for CRT implantation were prospectively studied. At baseline and after 6 month follow up two maximal cardiopulmonary exercise tests with and without regional circulatory occlusion (RCO) during recovery were performed. RCO was achieved by inflation of bilateral upper thigh tourniquets 30 mmHg above peak systolic blood pressure during 3 minutes after peak exercise. Metaboreflex contribution to the ventilatory response was assessed as the difference in ventilatory data at the third minute during recovery between the two tests (Δ). Results. Patients had enhanced VE/VCO(2) slope (40 ± 9) and an evident metaboreflex contribution to the high ventilatory response (ΔVE: 3 ± 4 L/min; P = 0.05, ΔRR: 4.5 ± 4/min; P = 0.003 and ΔVE/VCO(2): 5.5 ± 4; P = 0.007). 6 months after CRT implantation, NYHA class, LVEF, peak VO(2) and VE/VCO(2) were significantly improved (1.4 ± 0.5; P < 0.001, 42 ± 7%; P < 0.001, 16.5 ± 3 mL/kg/min; P = 0.003; 33 ± 10; P = 0.01). Metaboreflex contribution to VE, RR, and VE/VCO(2) was reduced compared with baseline (P = 0.08, P = 0.01 and P = 0.4 resp.). Conclusion. 6 months after CRT metaboreflex contribution to the ventilatory response is reduced. Hindawi Publishing Corporation 2012 2012-03-20 /pmc/articles/PMC3317128/ /pubmed/22536532 http://dx.doi.org/10.1155/2012/914071 Text en Copyright © 2012 Jérémie Jaussaud et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Clinical Study
Jaussaud, Jérémie
Aimable, Laurie
Bordachar, Pierre
Dos Santos, Pierre
Barandon, Laurent
Ritter, Philippe
Roudaut, Raymond
Douard, Hervé
Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population
title Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population
title_full Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population
title_fullStr Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population
title_full_unstemmed Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population
title_short Cardiac Resynchronization Therapy Reduces Metaboreflex Contribution to the Ventilatory Response in Heart Failure Population
title_sort cardiac resynchronization therapy reduces metaboreflex contribution to the ventilatory response in heart failure population
topic Clinical Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317128/
https://www.ncbi.nlm.nih.gov/pubmed/22536532
http://dx.doi.org/10.1155/2012/914071
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