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Inflammation as a Link between Obesity and Metabolic Syndrome
The metabolic syndrome is a complex of clinical features leading to an increased risk for cardiovascular disease and type 2 diabetes mellitus in both sexes. Visceral obesity and insulin resistance are considered the main features determining the negative cardiovascular profile in metabolic syndrome....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317136/ https://www.ncbi.nlm.nih.gov/pubmed/22523672 http://dx.doi.org/10.1155/2012/476380 |
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author | Emanuela, Faloia Grazia, Michetti Marco, De Robertis Maria Paola, Luconi Giorgio, Furlani Marco, Boscaro |
author_facet | Emanuela, Faloia Grazia, Michetti Marco, De Robertis Maria Paola, Luconi Giorgio, Furlani Marco, Boscaro |
author_sort | Emanuela, Faloia |
collection | PubMed |
description | The metabolic syndrome is a complex of clinical features leading to an increased risk for cardiovascular disease and type 2 diabetes mellitus in both sexes. Visceral obesity and insulin resistance are considered the main features determining the negative cardiovascular profile in metabolic syndrome. The aim of this paper is to highlight the central role of obesity in the development of a chronic low-grade inflammatory state that leads to insulin resistance, endothelial and microvascular dysfunctions. It is thought that the starting signal of this inflammation is overfeeding and the pathway origins in all the metabolic cells; the subsequent increase in cytokine production recruits immune cells in the extracellular environment inducing an overall systemic inflammation. This paper focuses on the molecular and cellular inflammatory mechanisms studied until now. |
format | Online Article Text |
id | pubmed-3317136 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33171362012-04-20 Inflammation as a Link between Obesity and Metabolic Syndrome Emanuela, Faloia Grazia, Michetti Marco, De Robertis Maria Paola, Luconi Giorgio, Furlani Marco, Boscaro J Nutr Metab Review Article The metabolic syndrome is a complex of clinical features leading to an increased risk for cardiovascular disease and type 2 diabetes mellitus in both sexes. Visceral obesity and insulin resistance are considered the main features determining the negative cardiovascular profile in metabolic syndrome. The aim of this paper is to highlight the central role of obesity in the development of a chronic low-grade inflammatory state that leads to insulin resistance, endothelial and microvascular dysfunctions. It is thought that the starting signal of this inflammation is overfeeding and the pathway origins in all the metabolic cells; the subsequent increase in cytokine production recruits immune cells in the extracellular environment inducing an overall systemic inflammation. This paper focuses on the molecular and cellular inflammatory mechanisms studied until now. Hindawi Publishing Corporation 2012 2012-03-01 /pmc/articles/PMC3317136/ /pubmed/22523672 http://dx.doi.org/10.1155/2012/476380 Text en Copyright © 2012 Faloia Emanuela et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Emanuela, Faloia Grazia, Michetti Marco, De Robertis Maria Paola, Luconi Giorgio, Furlani Marco, Boscaro Inflammation as a Link between Obesity and Metabolic Syndrome |
title | Inflammation as a Link between Obesity and Metabolic Syndrome |
title_full | Inflammation as a Link between Obesity and Metabolic Syndrome |
title_fullStr | Inflammation as a Link between Obesity and Metabolic Syndrome |
title_full_unstemmed | Inflammation as a Link between Obesity and Metabolic Syndrome |
title_short | Inflammation as a Link between Obesity and Metabolic Syndrome |
title_sort | inflammation as a link between obesity and metabolic syndrome |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317136/ https://www.ncbi.nlm.nih.gov/pubmed/22523672 http://dx.doi.org/10.1155/2012/476380 |
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