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The Molecular Biology of Brain Metastasis
Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in mo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317231/ https://www.ncbi.nlm.nih.gov/pubmed/22481931 http://dx.doi.org/10.1155/2012/723541 |
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author | Rahmathulla, Gazanfar Toms, Steven A. Weil, Robert J. |
author_facet | Rahmathulla, Gazanfar Toms, Steven A. Weil, Robert J. |
author_sort | Rahmathulla, Gazanfar |
collection | PubMed |
description | Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in molecular biology and genetics has advanced our knowledge of the underlying mechanisms involved, from invasion to final colonization of new organ tissues. Understanding the various events occurring at each stage should enable targeted drug delivery and individualized treatments for patients, with better outcomes and fewer side effects. This paper summarizes the principal molecular and genetic mechanisms that underlie the development of brain metastasis (BrM). |
format | Online Article Text |
id | pubmed-3317231 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33172312012-04-05 The Molecular Biology of Brain Metastasis Rahmathulla, Gazanfar Toms, Steven A. Weil, Robert J. J Oncol Review Article Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in molecular biology and genetics has advanced our knowledge of the underlying mechanisms involved, from invasion to final colonization of new organ tissues. Understanding the various events occurring at each stage should enable targeted drug delivery and individualized treatments for patients, with better outcomes and fewer side effects. This paper summarizes the principal molecular and genetic mechanisms that underlie the development of brain metastasis (BrM). Hindawi Publishing Corporation 2012 2012-03-08 /pmc/articles/PMC3317231/ /pubmed/22481931 http://dx.doi.org/10.1155/2012/723541 Text en Copyright © 2012 Gazanfar Rahmathulla et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Rahmathulla, Gazanfar Toms, Steven A. Weil, Robert J. The Molecular Biology of Brain Metastasis |
title | The Molecular Biology of Brain Metastasis |
title_full | The Molecular Biology of Brain Metastasis |
title_fullStr | The Molecular Biology of Brain Metastasis |
title_full_unstemmed | The Molecular Biology of Brain Metastasis |
title_short | The Molecular Biology of Brain Metastasis |
title_sort | molecular biology of brain metastasis |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317231/ https://www.ncbi.nlm.nih.gov/pubmed/22481931 http://dx.doi.org/10.1155/2012/723541 |
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