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The Molecular Biology of Brain Metastasis

Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in mo...

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Detalles Bibliográficos
Autores principales: Rahmathulla, Gazanfar, Toms, Steven A., Weil, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317231/
https://www.ncbi.nlm.nih.gov/pubmed/22481931
http://dx.doi.org/10.1155/2012/723541
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author Rahmathulla, Gazanfar
Toms, Steven A.
Weil, Robert J.
author_facet Rahmathulla, Gazanfar
Toms, Steven A.
Weil, Robert J.
author_sort Rahmathulla, Gazanfar
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description Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in molecular biology and genetics has advanced our knowledge of the underlying mechanisms involved, from invasion to final colonization of new organ tissues. Understanding the various events occurring at each stage should enable targeted drug delivery and individualized treatments for patients, with better outcomes and fewer side effects. This paper summarizes the principal molecular and genetic mechanisms that underlie the development of brain metastasis (BrM).
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spelling pubmed-33172312012-04-05 The Molecular Biology of Brain Metastasis Rahmathulla, Gazanfar Toms, Steven A. Weil, Robert J. J Oncol Review Article Metastasis to the central nervous system (CNS) remains a major cause of morbidity and mortality in patients with systemic cancers. Various crucial interactions between the brain environment and tumor cells take place during the development of the cancer at its new location. The rapid expansion in molecular biology and genetics has advanced our knowledge of the underlying mechanisms involved, from invasion to final colonization of new organ tissues. Understanding the various events occurring at each stage should enable targeted drug delivery and individualized treatments for patients, with better outcomes and fewer side effects. This paper summarizes the principal molecular and genetic mechanisms that underlie the development of brain metastasis (BrM). Hindawi Publishing Corporation 2012 2012-03-08 /pmc/articles/PMC3317231/ /pubmed/22481931 http://dx.doi.org/10.1155/2012/723541 Text en Copyright © 2012 Gazanfar Rahmathulla et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Rahmathulla, Gazanfar
Toms, Steven A.
Weil, Robert J.
The Molecular Biology of Brain Metastasis
title The Molecular Biology of Brain Metastasis
title_full The Molecular Biology of Brain Metastasis
title_fullStr The Molecular Biology of Brain Metastasis
title_full_unstemmed The Molecular Biology of Brain Metastasis
title_short The Molecular Biology of Brain Metastasis
title_sort molecular biology of brain metastasis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317231/
https://www.ncbi.nlm.nih.gov/pubmed/22481931
http://dx.doi.org/10.1155/2012/723541
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