Raf kinases mediate the phosphorylation of eukaryotic translation elongation factor 1A and regulate its stability in eukaryotic cells

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We identified eukaryotic translation elongation factor 1A (eEF1A) Raf-mediated phosphorylation sites and defined their role in the regulation of eEF1A half-life and of apoptosis of human cancer cells. Mass spectrometry identified in vitro S21 and T88 as phosphorylation sites mediated by B-Raf but no...

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Detalles Bibliográficos
Autores principales: Sanges, C, Scheuermann, C, Zahedi, R P, Sickmann, A, Lamberti, A, Migliaccio, N, Baljuls, A, Marra, M, Zappavigna, S, Rapp, U, Abbruzzese, A, Caraglia, M, Arcari, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317347/
https://www.ncbi.nlm.nih.gov/pubmed/22378069
http://dx.doi.org/10.1038/cddis.2012.16

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