HIV-1 Tat protein directly induces mitochondrial membrane permeabilization and inactivates cytochrome c oxidase

The Trans-activator protein (Tat) of human immunodeficiency virus (HIV) is a pleiotropic protein involved in different aspects of AIDS pathogenesis. As a number of viral proteins Tat is suspected to disturb mitochondrial function. We prepared pure synthetic full-length Tat by native chemical ligatio...

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Detalles Bibliográficos
Autores principales: Lecoeur, H, Borgne-Sanchez, A, Chaloin, O, El-Khoury, R, Brabant, M, Langonné, A, Porceddu, M, Brière, J-J, Buron, N, Rebouillat, D, Péchoux, C, Deniaud, A, Brenner, C, Briand, J-P, Muller, S, Rustin, P, Jacotot, E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2012
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317353/
https://www.ncbi.nlm.nih.gov/pubmed/22419111
http://dx.doi.org/10.1038/cddis.2012.21

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