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A patient with acquired hemophilia A induced by clopidogrel
Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies against factor VIII (FVIII). Treatment with clopidogrel is a cause of AHA, but its clinical course is unknown. Recently, we treated a 65-year-old man who was hospitalized for cerebellar infarction and had a prolonged ac...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317479/ https://www.ncbi.nlm.nih.gov/pubmed/22479283 http://dx.doi.org/10.5045/kjh.2012.47.1.80 |
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author | Hwang, Hye Won Kong, Jee Hyun Yu, Dong Wook Kim, Woo Taek Kim, Hyun Soo Lee, Chong In |
author_facet | Hwang, Hye Won Kong, Jee Hyun Yu, Dong Wook Kim, Woo Taek Kim, Hyun Soo Lee, Chong In |
author_sort | Hwang, Hye Won |
collection | PubMed |
description | Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies against factor VIII (FVIII). Treatment with clopidogrel is a cause of AHA, but its clinical course is unknown. Recently, we treated a 65-year-old man who was hospitalized for cerebellar infarction and had a prolonged activated partial thromboplastin time (aPTT) with soft tissue oozing after 3 weeks of clopidogrel use. We terminated clopidogrel administration and transfused the patient with fresh frozen plasma. However, the aPTT increased up to 98.8 seconds, and the FVIII and FVIII inhibitor levels were <1% and 5.4 Bethesda units/mL, respectively. Clopidogrel-associated AHA was considered, and we began steroid treatment. Two months later, FVIII, FVIII inhibitor, and aPTT values were normalized. No further bleeding or aPTT prolongation has been reported during the 2-year follow-up period. AHA should be considered in patients taking clopidogrel and experiencing bleeding, unless the platelet count and coagulation screen are normal. |
format | Online Article Text |
id | pubmed-3317479 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis |
record_format | MEDLINE/PubMed |
spelling | pubmed-33174792012-04-04 A patient with acquired hemophilia A induced by clopidogrel Hwang, Hye Won Kong, Jee Hyun Yu, Dong Wook Kim, Woo Taek Kim, Hyun Soo Lee, Chong In Korean J Hematol Case Report Acquired hemophilia A (AHA) is a rare bleeding disorder caused by autoantibodies against factor VIII (FVIII). Treatment with clopidogrel is a cause of AHA, but its clinical course is unknown. Recently, we treated a 65-year-old man who was hospitalized for cerebellar infarction and had a prolonged activated partial thromboplastin time (aPTT) with soft tissue oozing after 3 weeks of clopidogrel use. We terminated clopidogrel administration and transfused the patient with fresh frozen plasma. However, the aPTT increased up to 98.8 seconds, and the FVIII and FVIII inhibitor levels were <1% and 5.4 Bethesda units/mL, respectively. Clopidogrel-associated AHA was considered, and we began steroid treatment. Two months later, FVIII, FVIII inhibitor, and aPTT values were normalized. No further bleeding or aPTT prolongation has been reported during the 2-year follow-up period. AHA should be considered in patients taking clopidogrel and experiencing bleeding, unless the platelet count and coagulation screen are normal. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2012-03 2012-03-28 /pmc/articles/PMC3317479/ /pubmed/22479283 http://dx.doi.org/10.5045/kjh.2012.47.1.80 Text en © 2012 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Hwang, Hye Won Kong, Jee Hyun Yu, Dong Wook Kim, Woo Taek Kim, Hyun Soo Lee, Chong In A patient with acquired hemophilia A induced by clopidogrel |
title | A patient with acquired hemophilia A induced by clopidogrel |
title_full | A patient with acquired hemophilia A induced by clopidogrel |
title_fullStr | A patient with acquired hemophilia A induced by clopidogrel |
title_full_unstemmed | A patient with acquired hemophilia A induced by clopidogrel |
title_short | A patient with acquired hemophilia A induced by clopidogrel |
title_sort | patient with acquired hemophilia a induced by clopidogrel |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317479/ https://www.ncbi.nlm.nih.gov/pubmed/22479283 http://dx.doi.org/10.5045/kjh.2012.47.1.80 |
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