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Structural Insights into TIR Domain Specificity of the Bridging Adaptor Mal in TLR4 Signaling

MyD88 adaptor-like protein (Mal) is a crucial adaptor that acts as a bridge to recruit the MyD88 molecule to activated TLR4 receptors in response to invading pathogens. The specific assembly of the Toll/interleukin-1 receptor (TIR) domains of TLR4, Mal and MyD88 is responsible for proper signal tran...

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Detalles Bibliográficos
Autores principales:	Lin, Zhijie, Lu, Jing, Zhou, Weihong, Shen, Yuequan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317499/ https://www.ncbi.nlm.nih.gov/pubmed/22485159 http://dx.doi.org/10.1371/journal.pone.0034202

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