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Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor

To compare the antitumor efficacy and safety of transcatheter arterial chemoembolization (TACE) by epirubicin suspension (epirubicin suspension: epirubicin-iodized oil mixture without solution) to that by epirubicin emulsion (epirubicin emulsion: epirubicin-iodized oil mixture with solution), the ef...

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Autores principales: Ueda, Tatsuo, Murata, Satoru, Mine, Takahiko, Onozawa, Shiro, Onda, Munehiko, Naito, Zenya, Amano, Yasuo, Kumita, Shinichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Scientific World Journal 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317572/
https://www.ncbi.nlm.nih.gov/pubmed/22489208
http://dx.doi.org/10.1100/2012/961986
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author Ueda, Tatsuo
Murata, Satoru
Mine, Takahiko
Onozawa, Shiro
Onda, Munehiko
Naito, Zenya
Amano, Yasuo
Kumita, Shinichiro
author_facet Ueda, Tatsuo
Murata, Satoru
Mine, Takahiko
Onozawa, Shiro
Onda, Munehiko
Naito, Zenya
Amano, Yasuo
Kumita, Shinichiro
author_sort Ueda, Tatsuo
collection PubMed
description To compare the antitumor efficacy and safety of transcatheter arterial chemoembolization (TACE) by epirubicin suspension (epirubicin suspension: epirubicin-iodized oil mixture without solution) to that by epirubicin emulsion (epirubicin emulsion: epirubicin-iodized oil mixture with solution), the efficacy of treatment by administration of either an epirubicin suspension or emulsion was examined in an animal model. Changes in plasma epirubicin concentration were compared over 24 h immediately after treatment, and enhanced ultrasonographic and histopathological analysis subsequently conducted 7 days after treatment to determine the growth ratio and proportion of viable tumor cells. The growth ratio and proportion of viable tumor cells were found to be significantly lower in the suspension group than in the emulsion group while the plasma epirubicin concentration was found to be significantly higher in the suspension group than in the emulsion group. These results indicate that administration of an epirubicin suspension is a superior form of TACE compared to that of administration of an epirubicin emulsion.
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spelling pubmed-33175722012-04-09 Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor Ueda, Tatsuo Murata, Satoru Mine, Takahiko Onozawa, Shiro Onda, Munehiko Naito, Zenya Amano, Yasuo Kumita, Shinichiro ScientificWorldJournal Research Article To compare the antitumor efficacy and safety of transcatheter arterial chemoembolization (TACE) by epirubicin suspension (epirubicin suspension: epirubicin-iodized oil mixture without solution) to that by epirubicin emulsion (epirubicin emulsion: epirubicin-iodized oil mixture with solution), the efficacy of treatment by administration of either an epirubicin suspension or emulsion was examined in an animal model. Changes in plasma epirubicin concentration were compared over 24 h immediately after treatment, and enhanced ultrasonographic and histopathological analysis subsequently conducted 7 days after treatment to determine the growth ratio and proportion of viable tumor cells. The growth ratio and proportion of viable tumor cells were found to be significantly lower in the suspension group than in the emulsion group while the plasma epirubicin concentration was found to be significantly higher in the suspension group than in the emulsion group. These results indicate that administration of an epirubicin suspension is a superior form of TACE compared to that of administration of an epirubicin emulsion. The Scientific World Journal 2012-03-12 /pmc/articles/PMC3317572/ /pubmed/22489208 http://dx.doi.org/10.1100/2012/961986 Text en Copyright © 2012 Tatsuo Ueda et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ueda, Tatsuo
Murata, Satoru
Mine, Takahiko
Onozawa, Shiro
Onda, Munehiko
Naito, Zenya
Amano, Yasuo
Kumita, Shinichiro
Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor
title Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor
title_full Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor
title_fullStr Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor
title_full_unstemmed Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor
title_short Comparison of Epirubicin-Iodized Oil Suspension and Emulsion for Transcatheter Arterial Chemoembolization in VX2 Tumor
title_sort comparison of epirubicin-iodized oil suspension and emulsion for transcatheter arterial chemoembolization in vx2 tumor
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317572/
https://www.ncbi.nlm.nih.gov/pubmed/22489208
http://dx.doi.org/10.1100/2012/961986
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