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Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones
The diversified bis-isoquinolinones were obtained in two steps, utilizing homophthalic acid and various acid chlorides providing 3-substituted isocoumarins in the first step which on further condensation with 1,7-heptadiamine involving C–N bond formation from the lactone in the presence of 10 mol% z...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Scientific World Journal
2012
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317590/ https://www.ncbi.nlm.nih.gov/pubmed/22536149 http://dx.doi.org/10.1100/2012/619080 |
| _version_ | 1782228577196965888 |
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| author | Krishnakumar, Varadhan Mohan Kumar, Kesarla Mandal, Badal Kumar Khan, Fazlur-Rahman Nawaz |
| author_facet | Krishnakumar, Varadhan Mohan Kumar, Kesarla Mandal, Badal Kumar Khan, Fazlur-Rahman Nawaz |
| author_sort | Krishnakumar, Varadhan |
| collection | PubMed |
| description | The diversified bis-isoquinolinones were obtained in two steps, utilizing homophthalic acid and various acid chlorides providing 3-substituted isocoumarins in the first step which on further condensation with 1,7-heptadiamine involving C–N bond formation from the lactone in the presence of 10 mol% zinc oxide nanoparticles (ZnO NPs) (<150 nm) afforded the desired bis-isoquinolinones in high yield and purity. The synthesized compounds were then characterized using FTIR, (1)H NMR, (13)C NMR, and HRMS techniques. |
| format | Online Article Text |
| id | pubmed-3317590 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | The Scientific World Journal |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-33175902012-04-25 Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones Krishnakumar, Varadhan Mohan Kumar, Kesarla Mandal, Badal Kumar Khan, Fazlur-Rahman Nawaz ScientificWorldJournal Research Article The diversified bis-isoquinolinones were obtained in two steps, utilizing homophthalic acid and various acid chlorides providing 3-substituted isocoumarins in the first step which on further condensation with 1,7-heptadiamine involving C–N bond formation from the lactone in the presence of 10 mol% zinc oxide nanoparticles (ZnO NPs) (<150 nm) afforded the desired bis-isoquinolinones in high yield and purity. The synthesized compounds were then characterized using FTIR, (1)H NMR, (13)C NMR, and HRMS techniques. The Scientific World Journal 2012-03-12 /pmc/articles/PMC3317590/ /pubmed/22536149 http://dx.doi.org/10.1100/2012/619080 Text en Copyright © 2012 Varadhan Krishnakumar et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Research Article Krishnakumar, Varadhan Mohan Kumar, Kesarla Mandal, Badal Kumar Khan, Fazlur-Rahman Nawaz Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones |
| title | Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones |
| title_full | Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones |
| title_fullStr | Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones |
| title_full_unstemmed | Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones |
| title_short | Zinc Oxide Nanoparticles Catalyzed Condensation Reaction of Isocoumarins and 1,7-Heptadiamine in the Formation of Bis-Isoquinolinones |
| title_sort | zinc oxide nanoparticles catalyzed condensation reaction of isocoumarins and 1,7-heptadiamine in the formation of bis-isoquinolinones |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317590/ https://www.ncbi.nlm.nih.gov/pubmed/22536149 http://dx.doi.org/10.1100/2012/619080 |
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