Host genetic susceptibility to severe dengue infection

Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an...

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Detalles Bibliográficos
Autores principales: Lan, Nguyen Thi Phuong, Hirayama, Kenji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Tropical Medicine 2011
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317601/
https://www.ncbi.nlm.nih.gov/pubmed/22500139
http://dx.doi.org/10.2149/tmh.2011-S08
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author Lan, Nguyen Thi Phuong
Hirayama, Kenji
author_facet Lan, Nguyen Thi Phuong
Hirayama, Kenji
author_sort Lan, Nguyen Thi Phuong
collection PubMed
description Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options.
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spelling pubmed-33176012012-04-12 Host genetic susceptibility to severe dengue infection Lan, Nguyen Thi Phuong Hirayama, Kenji Trop Med Health Review Epidemiological evidence indicates that host genetic factors are relevant and predispose DHF/DSS development. Here, we review the host genetic studies concerning human leucocyte antigens, antibody receptors, immune/inflammatory mediators, attachment molecules, cytokines and other factors exerting an immunoregulatory effect as well as the current genome-wide association studies. We also discuss some viewpoints on future challenges related to the design of safe and effective prevention and treatment options. The Japanese Society of Tropical Medicine 2011-12 2011-10-12 /pmc/articles/PMC3317601/ /pubmed/22500139 http://dx.doi.org/10.2149/tmh.2011-S08 Text en © 2011 Japanese Society of Tropical Medicine This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lan, Nguyen Thi Phuong
Hirayama, Kenji
Host genetic susceptibility to severe dengue infection
title Host genetic susceptibility to severe dengue infection
title_full Host genetic susceptibility to severe dengue infection
title_fullStr Host genetic susceptibility to severe dengue infection
title_full_unstemmed Host genetic susceptibility to severe dengue infection
title_short Host genetic susceptibility to severe dengue infection
title_sort host genetic susceptibility to severe dengue infection
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317601/
https://www.ncbi.nlm.nih.gov/pubmed/22500139
http://dx.doi.org/10.2149/tmh.2011-S08
work_keys_str_mv AT lannguyenthiphuong hostgeneticsusceptibilitytoseveredengueinfection
AT hirayamakenji hostgeneticsusceptibilitytoseveredengueinfection

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