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T-cell Responses to Dengue Virus in Humans

Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8– and CD8+CD4– T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response...

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Detalles Bibliográficos
Autores principales: Kurane, Ichiro, Matsutani, Takaji, Suzuki, Ryuji, Takasaki, Tomohiko, Kalayanarooj, Siripen, Green, Sharone, Rothman, Alan L., Ennis, Francis A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Japanese Society of Tropical Medicine 2011
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317604/
https://www.ncbi.nlm.nih.gov/pubmed/22500136
http://dx.doi.org/10.2149/tmh.2011-S09
Descripción
Sumario:Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8– and CD8+CD4– T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response is to the serotype that caused the infection. The epitopes recognized by DENV-specific T cells are located in most of the structural and non-structural proteins, but NS3 is the protein that is most dominantly recognized. In patients with dengue hemorrhagic fever (DHF) caused by secondary DENV infection, T cells are highly activated in vivo. These highly activated T cells are DENV-specific and oligoclonal. Multiple kinds of lymphokines are produced by the activated T cells, and it has been hypothesized that these lymphokines are responsible for induction of plasma leakage, one of the most characteristic features of DHF. Thus, T-cells play important roles in the pathogenesis of DHF and in the recovery from DENV infection.