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T-cell Responses to Dengue Virus in Humans
Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8– and CD8+CD4– T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Tropical Medicine
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317604/ https://www.ncbi.nlm.nih.gov/pubmed/22500136 http://dx.doi.org/10.2149/tmh.2011-S09 |
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author | Kurane, Ichiro Matsutani, Takaji Suzuki, Ryuji Takasaki, Tomohiko Kalayanarooj, Siripen Green, Sharone Rothman, Alan L. Ennis, Francis A. |
author_facet | Kurane, Ichiro Matsutani, Takaji Suzuki, Ryuji Takasaki, Tomohiko Kalayanarooj, Siripen Green, Sharone Rothman, Alan L. Ennis, Francis A. |
author_sort | Kurane, Ichiro |
collection | PubMed |
description | Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8– and CD8+CD4– T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response is to the serotype that caused the infection. The epitopes recognized by DENV-specific T cells are located in most of the structural and non-structural proteins, but NS3 is the protein that is most dominantly recognized. In patients with dengue hemorrhagic fever (DHF) caused by secondary DENV infection, T cells are highly activated in vivo. These highly activated T cells are DENV-specific and oligoclonal. Multiple kinds of lymphokines are produced by the activated T cells, and it has been hypothesized that these lymphokines are responsible for induction of plasma leakage, one of the most characteristic features of DHF. Thus, T-cells play important roles in the pathogenesis of DHF and in the recovery from DENV infection. |
format | Online Article Text |
id | pubmed-3317604 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | The Japanese Society of Tropical Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-33176042012-04-12 T-cell Responses to Dengue Virus in Humans Kurane, Ichiro Matsutani, Takaji Suzuki, Ryuji Takasaki, Tomohiko Kalayanarooj, Siripen Green, Sharone Rothman, Alan L. Ennis, Francis A. Trop Med Health Review Dengue virus (DENV) is a leading cause of morbidity and mortality in most tropical and subtropical areas of the world. Dengue virus infection induces specific CD4+CD8– and CD8+CD4– T cells in humans. In primary infection, T-cell responses to DENV are serotype cross-reactive, but the highest response is to the serotype that caused the infection. The epitopes recognized by DENV-specific T cells are located in most of the structural and non-structural proteins, but NS3 is the protein that is most dominantly recognized. In patients with dengue hemorrhagic fever (DHF) caused by secondary DENV infection, T cells are highly activated in vivo. These highly activated T cells are DENV-specific and oligoclonal. Multiple kinds of lymphokines are produced by the activated T cells, and it has been hypothesized that these lymphokines are responsible for induction of plasma leakage, one of the most characteristic features of DHF. Thus, T-cells play important roles in the pathogenesis of DHF and in the recovery from DENV infection. The Japanese Society of Tropical Medicine 2011-12 2011-12-01 /pmc/articles/PMC3317604/ /pubmed/22500136 http://dx.doi.org/10.2149/tmh.2011-S09 Text en © 2011 Japanese Society of Tropical Medicine This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Kurane, Ichiro Matsutani, Takaji Suzuki, Ryuji Takasaki, Tomohiko Kalayanarooj, Siripen Green, Sharone Rothman, Alan L. Ennis, Francis A. T-cell Responses to Dengue Virus in Humans |
title | T-cell Responses to Dengue Virus in Humans |
title_full | T-cell Responses to Dengue Virus in Humans |
title_fullStr | T-cell Responses to Dengue Virus in Humans |
title_full_unstemmed | T-cell Responses to Dengue Virus in Humans |
title_short | T-cell Responses to Dengue Virus in Humans |
title_sort | t-cell responses to dengue virus in humans |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317604/ https://www.ncbi.nlm.nih.gov/pubmed/22500136 http://dx.doi.org/10.2149/tmh.2011-S09 |
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