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Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory
Complementing its primary role in motor control, cerebellar learning has also a bottom-up influence on cognitive functions, where high-level representations build up from elementary sensorimotor memories. In this paper we examine the cerebellar contribution to both procedural and declarative compone...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317659/ https://www.ncbi.nlm.nih.gov/pubmed/22485133 http://dx.doi.org/10.1371/journal.pone.0032560 |
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author | Passot, Jean-Baptiste Sheynikhovich, Denis Duvelle, Éléonore Arleo, Angelo |
author_facet | Passot, Jean-Baptiste Sheynikhovich, Denis Duvelle, Éléonore Arleo, Angelo |
author_sort | Passot, Jean-Baptiste |
collection | PubMed |
description | Complementing its primary role in motor control, cerebellar learning has also a bottom-up influence on cognitive functions, where high-level representations build up from elementary sensorimotor memories. In this paper we examine the cerebellar contribution to both procedural and declarative components of spatial cognition. To do so, we model a functional interplay between the cerebellum and the hippocampal formation during goal-oriented navigation. We reinterpret and complete existing genetic behavioural observations by means of quantitative accounts that cross-link synaptic plasticity mechanisms, single cell and population coding properties, and behavioural responses. In contrast to earlier hypotheses positing only a purely procedural impact of cerebellar adaptation deficits, our results suggest a cerebellar involvement in high-level aspects of behaviour. In particular, we propose that cerebellar learning mechanisms may influence hippocampal place fields, by contributing to the path integration process. Our simulations predict differences in place-cell discharge properties between normal mice and L7-PKCI mutant mice lacking long-term depression at cerebellar parallel fibre-Purkinje cell synapses. On the behavioural level, these results suggest that, by influencing the accuracy of hippocampal spatial codes, cerebellar deficits may impact the exploration-exploitation balance during spatial navigation. |
format | Online Article Text |
id | pubmed-3317659 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-33176592012-04-06 Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory Passot, Jean-Baptiste Sheynikhovich, Denis Duvelle, Éléonore Arleo, Angelo PLoS One Research Article Complementing its primary role in motor control, cerebellar learning has also a bottom-up influence on cognitive functions, where high-level representations build up from elementary sensorimotor memories. In this paper we examine the cerebellar contribution to both procedural and declarative components of spatial cognition. To do so, we model a functional interplay between the cerebellum and the hippocampal formation during goal-oriented navigation. We reinterpret and complete existing genetic behavioural observations by means of quantitative accounts that cross-link synaptic plasticity mechanisms, single cell and population coding properties, and behavioural responses. In contrast to earlier hypotheses positing only a purely procedural impact of cerebellar adaptation deficits, our results suggest a cerebellar involvement in high-level aspects of behaviour. In particular, we propose that cerebellar learning mechanisms may influence hippocampal place fields, by contributing to the path integration process. Our simulations predict differences in place-cell discharge properties between normal mice and L7-PKCI mutant mice lacking long-term depression at cerebellar parallel fibre-Purkinje cell synapses. On the behavioural level, these results suggest that, by influencing the accuracy of hippocampal spatial codes, cerebellar deficits may impact the exploration-exploitation balance during spatial navigation. Public Library of Science 2012-04-02 /pmc/articles/PMC3317659/ /pubmed/22485133 http://dx.doi.org/10.1371/journal.pone.0032560 Text en Passot et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Passot, Jean-Baptiste Sheynikhovich, Denis Duvelle, Éléonore Arleo, Angelo Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory |
title | Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory |
title_full | Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory |
title_fullStr | Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory |
title_full_unstemmed | Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory |
title_short | Contribution of Cerebellar Sensorimotor Adaptation to Hippocampal Spatial Memory |
title_sort | contribution of cerebellar sensorimotor adaptation to hippocampal spatial memory |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317659/ https://www.ncbi.nlm.nih.gov/pubmed/22485133 http://dx.doi.org/10.1371/journal.pone.0032560 |
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