Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation

Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to und...

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Autores principales: Arimitsu, Nagisa, Shimizu, Jun, Fujiwara, Naruyoshi, Takai, Kenji, Takada, Erika, Kono, Takao, Ueda, Yuji, Suzuki, Tomoko, Suzuki, Noboru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317678/
https://www.ncbi.nlm.nih.gov/pubmed/22489115
http://dx.doi.org/10.3390/ijms13032636
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author Arimitsu, Nagisa
Shimizu, Jun
Fujiwara, Naruyoshi
Takai, Kenji
Takada, Erika
Kono, Takao
Ueda, Yuji
Suzuki, Tomoko
Suzuki, Noboru
author_facet Arimitsu, Nagisa
Shimizu, Jun
Fujiwara, Naruyoshi
Takai, Kenji
Takada, Erika
Kono, Takao
Ueda, Yuji
Suzuki, Tomoko
Suzuki, Noboru
author_sort Arimitsu, Nagisa
collection PubMed
description Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to understand the molecular mechanisms governing neural regeneration of the damaged motor cortex after the transplantation. Recent investigations disclosed that chemokines participated in the regulation of migration and maturation of neural cell grafts. In this review, we summarize the involvement of inflammatory chemokines including stromal cell derived factor 1 (SDF1) in neural regeneration after ES cell derived neural stem/progenitor cell transplantation in mouse stroke models.
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spelling pubmed-33176782012-04-09 Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation Arimitsu, Nagisa Shimizu, Jun Fujiwara, Naruyoshi Takai, Kenji Takada, Erika Kono, Takao Ueda, Yuji Suzuki, Tomoko Suzuki, Noboru Int J Mol Sci Review Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a hemiplegic mouse model. It is important to understand the molecular mechanisms governing neural regeneration of the damaged motor cortex after the transplantation. Recent investigations disclosed that chemokines participated in the regulation of migration and maturation of neural cell grafts. In this review, we summarize the involvement of inflammatory chemokines including stromal cell derived factor 1 (SDF1) in neural regeneration after ES cell derived neural stem/progenitor cell transplantation in mouse stroke models. Molecular Diversity Preservation International (MDPI) 2012-02-28 /pmc/articles/PMC3317678/ /pubmed/22489115 http://dx.doi.org/10.3390/ijms13032636 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Arimitsu, Nagisa
Shimizu, Jun
Fujiwara, Naruyoshi
Takai, Kenji
Takada, Erika
Kono, Takao
Ueda, Yuji
Suzuki, Tomoko
Suzuki, Noboru
Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation
title Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation
title_full Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation
title_fullStr Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation
title_full_unstemmed Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation
title_short Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation
title_sort role of sdf1/cxcr4 interaction in experimental hemiplegic models with neural cell transplantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317678/
https://www.ncbi.nlm.nih.gov/pubmed/22489115
http://dx.doi.org/10.3390/ijms13032636
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