Cargando…
The Intriguing Life of Autophagosomes
Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane r...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317731/ https://www.ncbi.nlm.nih.gov/pubmed/22489171 http://dx.doi.org/10.3390/ijms13033618 |
_version_ | 1782228609913585664 |
---|---|
author | Mijaljica, Dalibor Prescott, Mark Devenish, Rodney J. |
author_facet | Mijaljica, Dalibor Prescott, Mark Devenish, Rodney J. |
author_sort | Mijaljica, Dalibor |
collection | PubMed |
description | Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at different stages of the macroautophagic process. Such events include exchange and flow of lipids and proteins between membranes and vesicles (e.g., during initiation and growth of the phagophore), vesicular positioning and trafficking within the cell (e.g., autophagosome location and movement) and fusion of autophagosomes with the boundary membranes of the degradative compartment. Here, we review current knowledge on the contribution of different organelles to the formation of autophagosomes, their trafficking and fate within the cell. We will consider some of the unresolved questions related to the molecular mechanisms that regulate the “life and death” of the autophagosome. |
format | Online Article Text |
id | pubmed-3317731 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-33177312012-04-09 The Intriguing Life of Autophagosomes Mijaljica, Dalibor Prescott, Mark Devenish, Rodney J. Int J Mol Sci Review Autophagosomes are double-membrane vesicles characteristic of macroautophagy, a degradative pathway for cytoplasmic material and organelles terminating in the lysosomal or vacuole compartment for mammals and yeast, respectively. This highly dynamic, multi-step process requires significant membrane reorganization events at different stages of the macroautophagic process. Such events include exchange and flow of lipids and proteins between membranes and vesicles (e.g., during initiation and growth of the phagophore), vesicular positioning and trafficking within the cell (e.g., autophagosome location and movement) and fusion of autophagosomes with the boundary membranes of the degradative compartment. Here, we review current knowledge on the contribution of different organelles to the formation of autophagosomes, their trafficking and fate within the cell. We will consider some of the unresolved questions related to the molecular mechanisms that regulate the “life and death” of the autophagosome. Molecular Diversity Preservation International (MDPI) 2012-03-19 /pmc/articles/PMC3317731/ /pubmed/22489171 http://dx.doi.org/10.3390/ijms13033618 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Mijaljica, Dalibor Prescott, Mark Devenish, Rodney J. The Intriguing Life of Autophagosomes |
title | The Intriguing Life of Autophagosomes |
title_full | The Intriguing Life of Autophagosomes |
title_fullStr | The Intriguing Life of Autophagosomes |
title_full_unstemmed | The Intriguing Life of Autophagosomes |
title_short | The Intriguing Life of Autophagosomes |
title_sort | intriguing life of autophagosomes |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317731/ https://www.ncbi.nlm.nih.gov/pubmed/22489171 http://dx.doi.org/10.3390/ijms13033618 |
work_keys_str_mv | AT mijaljicadalibor theintriguinglifeofautophagosomes AT prescottmark theintriguinglifeofautophagosomes AT devenishrodneyj theintriguinglifeofautophagosomes AT mijaljicadalibor intriguinglifeofautophagosomes AT prescottmark intriguinglifeofautophagosomes AT devenishrodneyj intriguinglifeofautophagosomes |