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Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project

There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for compound comparison (“read-across”), or for data mining to build predictive too...

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Detalles Bibliográficos
Autores principales: Briggs, Katharine, Cases, Montserrat, Heard, David J., Pastor, Manuel, Pognan, François, Sanz, Ferran, Schwab, Christof H., Steger-Hartmann, Thomas, Sutter, Andreas, Watson, David K., Wichard, Jörg D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317745/
https://www.ncbi.nlm.nih.gov/pubmed/22489185
http://dx.doi.org/10.3390/ijms13033820
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author Briggs, Katharine
Cases, Montserrat
Heard, David J.
Pastor, Manuel
Pognan, François
Sanz, Ferran
Schwab, Christof H.
Steger-Hartmann, Thomas
Sutter, Andreas
Watson, David K.
Wichard, Jörg D.
author_facet Briggs, Katharine
Cases, Montserrat
Heard, David J.
Pastor, Manuel
Pognan, François
Sanz, Ferran
Schwab, Christof H.
Steger-Hartmann, Thomas
Sutter, Andreas
Watson, David K.
Wichard, Jörg D.
author_sort Briggs, Katharine
collection PubMed
description There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for compound comparison (“read-across”), or for data mining to build predictive tools, should lead to a more efficient drug development process and contribute to the reduction of animal use (3Rs principle). In order to achieve these goals, a consortium approach, grouping numbers of relevant partners, is required. The eTOX (“electronic toxicity”) consortium represents such a project and is a public-private partnership within the framework of the European Innovative Medicines Initiative (IMI). The project aims at the development of in silico prediction systems for organ and in vivo toxicity. The backbone of the project will be a database consisting of preclinical toxicity data for drug compounds or candidates extracted from previously unpublished, legacy reports from thirteen European and European operation-based pharmaceutical companies. The database will be enhanced by incorporation of publically available, high quality toxicology data. Seven academic institutes and five small-to-medium size enterprises (SMEs) contribute with their expertise in data gathering, database curation, data mining, chemoinformatics and predictive systems development. The outcome of the project will be a predictive system contributing to early potential hazard identification and risk assessment during the drug development process. The concept and strategy of the eTOX project is described here, together with current achievements and future deliverables.
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spelling pubmed-33177452012-04-09 Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project Briggs, Katharine Cases, Montserrat Heard, David J. Pastor, Manuel Pognan, François Sanz, Ferran Schwab, Christof H. Steger-Hartmann, Thomas Sutter, Andreas Watson, David K. Wichard, Jörg D. Int J Mol Sci Review There is a widespread awareness that the wealth of preclinical toxicity data that the pharmaceutical industry has generated in recent decades is not exploited as efficiently as it could be. Enhanced data availability for compound comparison (“read-across”), or for data mining to build predictive tools, should lead to a more efficient drug development process and contribute to the reduction of animal use (3Rs principle). In order to achieve these goals, a consortium approach, grouping numbers of relevant partners, is required. The eTOX (“electronic toxicity”) consortium represents such a project and is a public-private partnership within the framework of the European Innovative Medicines Initiative (IMI). The project aims at the development of in silico prediction systems for organ and in vivo toxicity. The backbone of the project will be a database consisting of preclinical toxicity data for drug compounds or candidates extracted from previously unpublished, legacy reports from thirteen European and European operation-based pharmaceutical companies. The database will be enhanced by incorporation of publically available, high quality toxicology data. Seven academic institutes and five small-to-medium size enterprises (SMEs) contribute with their expertise in data gathering, database curation, data mining, chemoinformatics and predictive systems development. The outcome of the project will be a predictive system contributing to early potential hazard identification and risk assessment during the drug development process. The concept and strategy of the eTOX project is described here, together with current achievements and future deliverables. Molecular Diversity Preservation International (MDPI) 2012-03-21 /pmc/articles/PMC3317745/ /pubmed/22489185 http://dx.doi.org/10.3390/ijms13033820 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Briggs, Katharine
Cases, Montserrat
Heard, David J.
Pastor, Manuel
Pognan, François
Sanz, Ferran
Schwab, Christof H.
Steger-Hartmann, Thomas
Sutter, Andreas
Watson, David K.
Wichard, Jörg D.
Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project
title Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project
title_full Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project
title_fullStr Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project
title_full_unstemmed Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project
title_short Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project
title_sort inroads to predict in vivo toxicology—an introduction to the etox project
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317745/
https://www.ncbi.nlm.nih.gov/pubmed/22489185
http://dx.doi.org/10.3390/ijms13033820
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