Cargando…

Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer

Curcumin, a yellow pigment derived from Curcuma longa Linn, has attracted great interest in the research of cancer during the past decades. Extensive studies documented that curcumin attenuates cancer cell proliferation and promotes apoptosis in vivo and in vitro. Curcumin has been demonstrated to i...

Descripción completa

Detalles Bibliográficos
Autores principales: Ye, Ming-Xiang, Li, Yan, Yin, Hong, Zhang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317752/
https://www.ncbi.nlm.nih.gov/pubmed/22489192
http://dx.doi.org/10.3390/ijms13033959
_version_ 1782228614842941440
author Ye, Ming-Xiang
Li, Yan
Yin, Hong
Zhang, Jian
author_facet Ye, Ming-Xiang
Li, Yan
Yin, Hong
Zhang, Jian
author_sort Ye, Ming-Xiang
collection PubMed
description Curcumin, a yellow pigment derived from Curcuma longa Linn, has attracted great interest in the research of cancer during the past decades. Extensive studies documented that curcumin attenuates cancer cell proliferation and promotes apoptosis in vivo and in vitro. Curcumin has been demonstrated to interact with multiple molecules and signal pathways, which makes it a potential adjuvant anti-cancer agent to chemotherapy. Previous investigations focus on the mechanisms of action for curcumin, which is shown to manipulate transcription factors and induce apoptosis in various kinds of human cancer. Apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (EGFR), microRNAs (miRNA), autophagy and cancer stem cell. The present review predominantly discusses significance of EGFR, miRNA, autophagy and cancer stem cell in lung cancer therapy. Curcumin as a natural phytochemicals could communicate with these novel targets and show synergism to chemotherapy. Additionally, curcumin is well tolerated in humans. Therefore, EGFR-, miRNA-, autophagy- and cancer stem cell-based therapy in the presence of curcumin might be promising mechanisms and targets in the therapeutic strategy of lung cancer.
format Online
Article
Text
id pubmed-3317752
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-33177522012-04-09 Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer Ye, Ming-Xiang Li, Yan Yin, Hong Zhang, Jian Int J Mol Sci Review Curcumin, a yellow pigment derived from Curcuma longa Linn, has attracted great interest in the research of cancer during the past decades. Extensive studies documented that curcumin attenuates cancer cell proliferation and promotes apoptosis in vivo and in vitro. Curcumin has been demonstrated to interact with multiple molecules and signal pathways, which makes it a potential adjuvant anti-cancer agent to chemotherapy. Previous investigations focus on the mechanisms of action for curcumin, which is shown to manipulate transcription factors and induce apoptosis in various kinds of human cancer. Apart from transcription factors and apoptosis, emerging studies shed light on latent targets of curcumin against epidermal growth factor receptor (EGFR), microRNAs (miRNA), autophagy and cancer stem cell. The present review predominantly discusses significance of EGFR, miRNA, autophagy and cancer stem cell in lung cancer therapy. Curcumin as a natural phytochemicals could communicate with these novel targets and show synergism to chemotherapy. Additionally, curcumin is well tolerated in humans. Therefore, EGFR-, miRNA-, autophagy- and cancer stem cell-based therapy in the presence of curcumin might be promising mechanisms and targets in the therapeutic strategy of lung cancer. Molecular Diversity Preservation International (MDPI) 2012-03-22 /pmc/articles/PMC3317752/ /pubmed/22489192 http://dx.doi.org/10.3390/ijms13033959 Text en © 2012 by the authors; licensee Molecular Diversity Preservation International, Basel, Switzerland. http://creativecommons.org/licenses/by/3.0 This article is an open-access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Ye, Ming-Xiang
Li, Yan
Yin, Hong
Zhang, Jian
Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer
title Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer
title_full Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer
title_fullStr Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer
title_full_unstemmed Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer
title_short Curcumin: Updated Molecular Mechanisms and Intervention Targets in Human Lung Cancer
title_sort curcumin: updated molecular mechanisms and intervention targets in human lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317752/
https://www.ncbi.nlm.nih.gov/pubmed/22489192
http://dx.doi.org/10.3390/ijms13033959
work_keys_str_mv AT yemingxiang curcuminupdatedmolecularmechanismsandinterventiontargetsinhumanlungcancer
AT liyan curcuminupdatedmolecularmechanismsandinterventiontargetsinhumanlungcancer
AT yinhong curcuminupdatedmolecularmechanismsandinterventiontargetsinhumanlungcancer
AT zhangjian curcuminupdatedmolecularmechanismsandinterventiontargetsinhumanlungcancer