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A Cellular Automata-based Model for Simulating Restitution Property in a Single Heart Cell
Ventricular fibrillation is the cause of the most sudden mortalities. Restitution is one of the specific properties of ventricular cell. The recent findings have clearly proved the correlation between the slope of restitution curve with ventricular fibrillation. This; therefore, mandates the modelin...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2011
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317760/ https://www.ncbi.nlm.nih.gov/pubmed/22606655 |
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author | Sabzpoushan, Seyed Hojjat Pourhasanzade, Fateme |
author_facet | Sabzpoushan, Seyed Hojjat Pourhasanzade, Fateme |
author_sort | Sabzpoushan, Seyed Hojjat |
collection | PubMed |
description | Ventricular fibrillation is the cause of the most sudden mortalities. Restitution is one of the specific properties of ventricular cell. The recent findings have clearly proved the correlation between the slope of restitution curve with ventricular fibrillation. This; therefore, mandates the modeling of cellular restitution to gain high importance. A cellular automaton is a powerful tool for simulating complex phenomena in a simple language. A cellular automaton is a lattice of cells where the behavior of each cell is determined by the behavior of its neighboring cells as well as the automata rule. In this paper, a simple model is depicted for the simulation of the property of restitution in a single cardiac cell using cellular automata. At first, two state variables; action potential and recovery are introduced in the automata model. In second, automata rule is determined and then recovery variable is defined in such a way so that the restitution is developed. In order to evaluate the proposed model, the generated restitution curve in our study is compared with the restitution curves from the experimental findings of valid sources. Our findings indicate that the presented model is not only capable of simulating restitution in cardiac cell, but also possesses the capability of regulating the restitution curve. |
format | Online Article Text |
id | pubmed-3317760 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2011 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-33177602012-05-09 A Cellular Automata-based Model for Simulating Restitution Property in a Single Heart Cell Sabzpoushan, Seyed Hojjat Pourhasanzade, Fateme J Med Signals Sens Original Article Ventricular fibrillation is the cause of the most sudden mortalities. Restitution is one of the specific properties of ventricular cell. The recent findings have clearly proved the correlation between the slope of restitution curve with ventricular fibrillation. This; therefore, mandates the modeling of cellular restitution to gain high importance. A cellular automaton is a powerful tool for simulating complex phenomena in a simple language. A cellular automaton is a lattice of cells where the behavior of each cell is determined by the behavior of its neighboring cells as well as the automata rule. In this paper, a simple model is depicted for the simulation of the property of restitution in a single cardiac cell using cellular automata. At first, two state variables; action potential and recovery are introduced in the automata model. In second, automata rule is determined and then recovery variable is defined in such a way so that the restitution is developed. In order to evaluate the proposed model, the generated restitution curve in our study is compared with the restitution curves from the experimental findings of valid sources. Our findings indicate that the presented model is not only capable of simulating restitution in cardiac cell, but also possesses the capability of regulating the restitution curve. Medknow Publications & Media Pvt Ltd 2011 /pmc/articles/PMC3317760/ /pubmed/22606655 Text en Copyright: © Journal of Medical Signals and Sensors http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Sabzpoushan, Seyed Hojjat Pourhasanzade, Fateme A Cellular Automata-based Model for Simulating Restitution Property in a Single Heart Cell |
title | A Cellular Automata-based Model for Simulating Restitution Property in a Single Heart Cell |
title_full | A Cellular Automata-based Model for Simulating Restitution Property in a Single Heart Cell |
title_fullStr | A Cellular Automata-based Model for Simulating Restitution Property in a Single Heart Cell |
title_full_unstemmed | A Cellular Automata-based Model for Simulating Restitution Property in a Single Heart Cell |
title_short | A Cellular Automata-based Model for Simulating Restitution Property in a Single Heart Cell |
title_sort | cellular automata-based model for simulating restitution property in a single heart cell |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317760/ https://www.ncbi.nlm.nih.gov/pubmed/22606655 |
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