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Tract Specific Reproducibility of Tractography Based Morphology and Diffusion Metrics

INTRODUCTION: The reproducibility of tractography is important to determine its sensitivity to pathological abnormalities. The reproducibility of tract morphology has not yet been systematically studied and the recently developed tractography contrast Tract Density Imaging (TDI) has not yet been ass...

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Autores principales: Besseling, René M. H., Jansen, Jacobus F. A., Overvliet, Geke M., Vaessen, Maarten J., Braakman, Hilde M. H., Hofman, Paul A. M., Aldenkamp, Albert P., Backes, Walter H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317780/
https://www.ncbi.nlm.nih.gov/pubmed/22485157
http://dx.doi.org/10.1371/journal.pone.0034125
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author Besseling, René M. H.
Jansen, Jacobus F. A.
Overvliet, Geke M.
Vaessen, Maarten J.
Braakman, Hilde M. H.
Hofman, Paul A. M.
Aldenkamp, Albert P.
Backes, Walter H.
author_facet Besseling, René M. H.
Jansen, Jacobus F. A.
Overvliet, Geke M.
Vaessen, Maarten J.
Braakman, Hilde M. H.
Hofman, Paul A. M.
Aldenkamp, Albert P.
Backes, Walter H.
author_sort Besseling, René M. H.
collection PubMed
description INTRODUCTION: The reproducibility of tractography is important to determine its sensitivity to pathological abnormalities. The reproducibility of tract morphology has not yet been systematically studied and the recently developed tractography contrast Tract Density Imaging (TDI) has not yet been assessed at the tract specific level. MATERIALS AND METHODS: Diffusion tensor imaging (DTI) and probabilistic constrained spherical deconvolution (CSD) tractography are performed twice in 9 healthy subjects. Tractography is based on common space seed and target regions and performed for several major white matter tracts. Tractograms are converted to tract segmentations and inter-session reproducibility of tract morphology is assessed using Dice similarity coefficient (DSC). The coefficient of variation (COV) and intraclass correlation coefficient (ICC) are calculated of the following tract metrics: fractional anisotropy (FA), apparent diffusion coefficient (ADC), volume, and TDI. Analyses are performed both for proximal (deep white matter) and extended (including subcortical white matter) tract segmentations. RESULTS: Proximal DSC values were 0.70–0.92. DSC values were 5–10% lower in extended compared to proximal segmentations. COV/ICC values of FA, ADC, volume and TDI were 1–4%/0.65–0.94, 2–4%/0.62–0.94, 3–22%/0.53–0.96 and 8–31%/0.48–0.70, respectively, with the lower COV and higher ICC values found in the proximal segmentations. CONCLUSION: For all investigated metrics, reproducibility depended on the segmented tract. FA and ADC had relatively low COV and relatively high ICC, indicating clinical potential. Volume had higher COV but its moderate to high ICC values in most tracts still suggest subject-differentiating power. Tract TDI had high COV and relatively low ICC, which reflects unfavorable reproducibility.
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spelling pubmed-33177802012-04-06 Tract Specific Reproducibility of Tractography Based Morphology and Diffusion Metrics Besseling, René M. H. Jansen, Jacobus F. A. Overvliet, Geke M. Vaessen, Maarten J. Braakman, Hilde M. H. Hofman, Paul A. M. Aldenkamp, Albert P. Backes, Walter H. PLoS One Research Article INTRODUCTION: The reproducibility of tractography is important to determine its sensitivity to pathological abnormalities. The reproducibility of tract morphology has not yet been systematically studied and the recently developed tractography contrast Tract Density Imaging (TDI) has not yet been assessed at the tract specific level. MATERIALS AND METHODS: Diffusion tensor imaging (DTI) and probabilistic constrained spherical deconvolution (CSD) tractography are performed twice in 9 healthy subjects. Tractography is based on common space seed and target regions and performed for several major white matter tracts. Tractograms are converted to tract segmentations and inter-session reproducibility of tract morphology is assessed using Dice similarity coefficient (DSC). The coefficient of variation (COV) and intraclass correlation coefficient (ICC) are calculated of the following tract metrics: fractional anisotropy (FA), apparent diffusion coefficient (ADC), volume, and TDI. Analyses are performed both for proximal (deep white matter) and extended (including subcortical white matter) tract segmentations. RESULTS: Proximal DSC values were 0.70–0.92. DSC values were 5–10% lower in extended compared to proximal segmentations. COV/ICC values of FA, ADC, volume and TDI were 1–4%/0.65–0.94, 2–4%/0.62–0.94, 3–22%/0.53–0.96 and 8–31%/0.48–0.70, respectively, with the lower COV and higher ICC values found in the proximal segmentations. CONCLUSION: For all investigated metrics, reproducibility depended on the segmented tract. FA and ADC had relatively low COV and relatively high ICC, indicating clinical potential. Volume had higher COV but its moderate to high ICC values in most tracts still suggest subject-differentiating power. Tract TDI had high COV and relatively low ICC, which reflects unfavorable reproducibility. Public Library of Science 2012-04-02 /pmc/articles/PMC3317780/ /pubmed/22485157 http://dx.doi.org/10.1371/journal.pone.0034125 Text en Besseling et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Besseling, René M. H.
Jansen, Jacobus F. A.
Overvliet, Geke M.
Vaessen, Maarten J.
Braakman, Hilde M. H.
Hofman, Paul A. M.
Aldenkamp, Albert P.
Backes, Walter H.
Tract Specific Reproducibility of Tractography Based Morphology and Diffusion Metrics
title Tract Specific Reproducibility of Tractography Based Morphology and Diffusion Metrics
title_full Tract Specific Reproducibility of Tractography Based Morphology and Diffusion Metrics
title_fullStr Tract Specific Reproducibility of Tractography Based Morphology and Diffusion Metrics
title_full_unstemmed Tract Specific Reproducibility of Tractography Based Morphology and Diffusion Metrics
title_short Tract Specific Reproducibility of Tractography Based Morphology and Diffusion Metrics
title_sort tract specific reproducibility of tractography based morphology and diffusion metrics
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317780/
https://www.ncbi.nlm.nih.gov/pubmed/22485157
http://dx.doi.org/10.1371/journal.pone.0034125
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