KSAC, a Defined Leishmania Antigen, plus Adjuvant Protects against the Virulence of L. major Transmitted by Its Natural Vector Phlebotomus duboscqi

BACKGROUND: Recombinant KSAC and L110f are promising Leishmania vaccine candidates. Both antigens formulated in stable emulsions (SE) with the natural TLR4 agonist MPL® and L110f with the synthetic TLR4 agonist GLA in SE protected BALB/c mice against L. major infection following needle challenge. Co...

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Detalles Bibliográficos
Autores principales: Gomes, Regis, Teixeira, Clarissa, Oliveira, Fabiano, Lawyer, Phillip G., Elnaiem, Dia-Eldin, Meneses, Claudio, Goto, Yasuyuki, Bhatia, Ajay, Howard, Randall F., Reed, Steven G., Valenzuela, Jesus G., Kamhawi, Shaden
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317914/
https://www.ncbi.nlm.nih.gov/pubmed/22509423
http://dx.doi.org/10.1371/journal.pntd.0001610

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