Efficacy of a Non-Hypercalcemic Vitamin-D2 Derived Anti-Cancer Agent (MT19c) and Inhibition of Fatty Acid Synthesis in an Ovarian Cancer Xenograft Model

BACKGROUND: Numerous vitamin-D analogs exhibited poor response rates, high systemic toxicities and hypercalcemia in human trials to treat cancer. We identified the first non-hypercalcemic anti-cancer vitamin D analog MT19c by altering the A-ring of ergocalciferol. This study describes the therapeuti...

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Detalles Bibliográficos
Autores principales: Moore, Richard G., Lange, Thilo S., Robinson, Katina, Kim, Kyu K., Uzun, Alper, Horan, Timothy C., Kawar, Nada, Yano, Naohiro, Chu, Sharon R., Mao, Quanfu, Brard, Laurent, DePaepe, Monique E., Padbury, James F., Arnold, Leggy A., Brodsky, Alexander, Shen, Tun-Li, Singh, Rakesh K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317945/
https://www.ncbi.nlm.nih.gov/pubmed/22509304
http://dx.doi.org/10.1371/journal.pone.0034443

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