The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment

HIV protease inhibitors (PIs) show antimalarial activity in vitro and in animals. Whether this translates into a clinical benefit in HIV-infected patients residing in malaria-endemic regions is unknown. We studied the incidence of malaria, as defined by blood smear positivity or a positive Plasmodiu...

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Autores principales: Skinner-Adams, Tina S., Butterworth, Alice S., Porter, Kimberly A., D'Amico, Ronald, Sawe, Fred, Shaffer, Doug, Siika, Abraham, Hosseinipour, Mina C., Stringer, Elizabeth, Currier, Judith S., Chipato, Tsungai, Salata, Robert, Lockman, Shahin, Eron, Joseph J., Meshnick, Steven R., McCarthy, James S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317955/
https://www.ncbi.nlm.nih.gov/pubmed/22509297
http://dx.doi.org/10.1371/journal.pone.0034399
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author Skinner-Adams, Tina S.
Butterworth, Alice S.
Porter, Kimberly A.
D'Amico, Ronald
Sawe, Fred
Shaffer, Doug
Siika, Abraham
Hosseinipour, Mina C.
Stringer, Elizabeth
Currier, Judith S.
Chipato, Tsungai
Salata, Robert
Lockman, Shahin
Eron, Joseph J.
Meshnick, Steven R.
McCarthy, James S.
author_facet Skinner-Adams, Tina S.
Butterworth, Alice S.
Porter, Kimberly A.
D'Amico, Ronald
Sawe, Fred
Shaffer, Doug
Siika, Abraham
Hosseinipour, Mina C.
Stringer, Elizabeth
Currier, Judith S.
Chipato, Tsungai
Salata, Robert
Lockman, Shahin
Eron, Joseph J.
Meshnick, Steven R.
McCarthy, James S.
author_sort Skinner-Adams, Tina S.
collection PubMed
description HIV protease inhibitors (PIs) show antimalarial activity in vitro and in animals. Whether this translates into a clinical benefit in HIV-infected patients residing in malaria-endemic regions is unknown. We studied the incidence of malaria, as defined by blood smear positivity or a positive Plasmodium falciparum histidine-rich protein 2 antigen test, among 444 HIV-infected women initiating antiretroviral treatment (ART) in the OCTANE trial (A5208; ClinicalTrials.gov: NCT00089505). Participants were randomized to treatment with PI-containing vs. PI-sparing ART, and were followed prospectively for ≥48 weeks; 73% also received cotrimoxazole prophylaxis. PI-containing treatment was not associated with protection against malaria in this study population.
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spelling pubmed-33179552012-04-16 The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment Skinner-Adams, Tina S. Butterworth, Alice S. Porter, Kimberly A. D'Amico, Ronald Sawe, Fred Shaffer, Doug Siika, Abraham Hosseinipour, Mina C. Stringer, Elizabeth Currier, Judith S. Chipato, Tsungai Salata, Robert Lockman, Shahin Eron, Joseph J. Meshnick, Steven R. McCarthy, James S. PLoS One Research Article HIV protease inhibitors (PIs) show antimalarial activity in vitro and in animals. Whether this translates into a clinical benefit in HIV-infected patients residing in malaria-endemic regions is unknown. We studied the incidence of malaria, as defined by blood smear positivity or a positive Plasmodium falciparum histidine-rich protein 2 antigen test, among 444 HIV-infected women initiating antiretroviral treatment (ART) in the OCTANE trial (A5208; ClinicalTrials.gov: NCT00089505). Participants were randomized to treatment with PI-containing vs. PI-sparing ART, and were followed prospectively for ≥48 weeks; 73% also received cotrimoxazole prophylaxis. PI-containing treatment was not associated with protection against malaria in this study population. Public Library of Science 2012-04-03 /pmc/articles/PMC3317955/ /pubmed/22509297 http://dx.doi.org/10.1371/journal.pone.0034399 Text en Skinner-Adams et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Skinner-Adams, Tina S.
Butterworth, Alice S.
Porter, Kimberly A.
D'Amico, Ronald
Sawe, Fred
Shaffer, Doug
Siika, Abraham
Hosseinipour, Mina C.
Stringer, Elizabeth
Currier, Judith S.
Chipato, Tsungai
Salata, Robert
Lockman, Shahin
Eron, Joseph J.
Meshnick, Steven R.
McCarthy, James S.
The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment
title The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment
title_full The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment
title_fullStr The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment
title_full_unstemmed The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment
title_short The Frequency of Malaria Is Similar among Women Receiving either Lopinavir/Ritonavir or Nevirapine-based Antiretroviral Treatment
title_sort frequency of malaria is similar among women receiving either lopinavir/ritonavir or nevirapine-based antiretroviral treatment
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317955/
https://www.ncbi.nlm.nih.gov/pubmed/22509297
http://dx.doi.org/10.1371/journal.pone.0034399
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