Erythropoietin Receptor Signaling Is Membrane Raft Dependent

Upon erythropoietin (Epo) engagement, Epo-receptor (R) homodimerizes to activate JAK2 and Lyn, which phosphorylate STAT5. Although recent investigations have identified key negative regulators of Epo-R signaling, little is known about the role of membrane localization in controlling receptor signal...

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Detalles Bibliográficos
Autores principales: McGraw, Kathy L., Fuhler, Gwenny M., Johnson, Joseph O., Clark, Justine A., Caceres, Gisela C., Sokol, Lubomir, List, Alan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317978/
https://www.ncbi.nlm.nih.gov/pubmed/22509308
http://dx.doi.org/10.1371/journal.pone.0034477

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