A Common Role for Various Human Truncated Adenomatous Polyposis Coli Isoforms in the Control of Beta-Catenin Activity and Cell Proliferation

The tumour suppressor gene adenomatous polyposis coli (APC) is mutated in most colorectal cancer cases, leading to the synthesis of truncated APC products and the stabilization of β-catenin. Truncated APC is almost always retained in tumour cells, suggesting that it serves an essential function. Her...

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Detalles Bibliográficos
Autores principales: Vijaya Chandra, Shree Harsha, Wacker, Ingrid, Appelt, Uwe Kurt, Behrens, Jürgen, Schneikert, Jean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3317983/
https://www.ncbi.nlm.nih.gov/pubmed/22509309
http://dx.doi.org/10.1371/journal.pone.0034479

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