Modulation of Astrocytic Mitochondrial Function by Dichloroacetate Improves Survival and Motor Performance in Inherited Amyotrophic Lateral Sclerosis

Mitochondrial dysfunction is one of the pathogenic mechanisms that lead to neurodegeneration in Amyotrophic Lateral Sclerosis (ALS). Astrocytes expressing the ALS-linked SOD1(G93A) mutation display a decreased mitochondrial respiratory capacity associated to phenotypic changes that cause them to ind...

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Detalles Bibliográficos
Autores principales: Miquel, Ernesto, Cassina, Adriana, Martínez-Palma, Laura, Bolatto, Carmen, Trías, Emiliano, Gandelman, Mandi, Radi, Rafael, Barbeito, Luis, Cassina, Patricia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318006/
https://www.ncbi.nlm.nih.gov/pubmed/22509356
http://dx.doi.org/10.1371/journal.pone.0034776

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