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Proinsulin Atypical Maturation and Disposal Induces Extensive Defects in Mouse Ins2(+/Akita) β-Cells

Because of its low relative folding rate and plentiful manufacture in β-cells, proinsulin maintains a homeostatic balance of natively and plentiful non-natively folded states (i.e., proinsulin homeostasis, PIHO) through the integration of maturation and disposal processes. PIHO is susceptible to gen...

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Detalles Bibliográficos
Autores principales:	Yuan, Qingxin, Tang, Wei, Zhang, Xiaoping, Hinson, Jack A., Liu, Chao, Osei, Kwame, Wang, Jie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318013/ https://www.ncbi.nlm.nih.gov/pubmed/22509386 http://dx.doi.org/10.1371/journal.pone.0035098

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