Telomeres in disease

Telomeres and telomere repair are basic molecular features of cells possessing linear DNA chromosomes and defects in them result in various diseases. This review examines recent advances in understanding these diseases, particularly at a molecular level, and in relating telomere dysfunction to clini...

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Detalles Bibliográficos
Autores principales: Calado, Rodrigo, Young, Neal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Faculty of 1000 Ltd 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318193/
https://www.ncbi.nlm.nih.gov/pubmed/22500192
http://dx.doi.org/10.3410/M4-8
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author Calado, Rodrigo
Young, Neal
author_facet Calado, Rodrigo
Young, Neal
author_sort Calado, Rodrigo
collection PubMed
description Telomeres and telomere repair are basic molecular features of cells possessing linear DNA chromosomes and defects in them result in various diseases. This review examines recent advances in understanding these diseases, particularly at a molecular level, and in relating telomere dysfunction to clinical diseases. We also discuss the potential role of telomere elongation as a therapy in diseases, and more controversially, the prevention/reversal of aging.
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spelling pubmed-33181932012-04-12 Telomeres in disease Calado, Rodrigo Young, Neal F1000 Med Rep Review Article Telomeres and telomere repair are basic molecular features of cells possessing linear DNA chromosomes and defects in them result in various diseases. This review examines recent advances in understanding these diseases, particularly at a molecular level, and in relating telomere dysfunction to clinical diseases. We also discuss the potential role of telomere elongation as a therapy in diseases, and more controversially, the prevention/reversal of aging. Faculty of 1000 Ltd 2012-04-02 /pmc/articles/PMC3318193/ /pubmed/22500192 http://dx.doi.org/10.3410/M4-8 Text en © 2012 Faculty of 1000 Ltd http://creativecommons.org/licenses/by-nc/3.0/legalcode This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. You may not use this work for commercial purposes
spellingShingle Review Article
Calado, Rodrigo
Young, Neal
Telomeres in disease
title Telomeres in disease
title_full Telomeres in disease
title_fullStr Telomeres in disease
title_full_unstemmed Telomeres in disease
title_short Telomeres in disease
title_sort telomeres in disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318193/
https://www.ncbi.nlm.nih.gov/pubmed/22500192
http://dx.doi.org/10.3410/M4-8
work_keys_str_mv AT caladorodrigo telomeresindisease
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