Cargando…
Challenges in Providing Treatment and Care for Viral Hepatitis among Individuals Co-Infected with HIV in Resource-Limited Settings
Hepatitis B and C infections are prevalent among HIV-infected individuals with different epidemiologic profiles, modes of transmission, natural histories, and treatments. Southeast Asian countries are classified as “highly prevalent zones,” with a rate of hepatitis B and C coinfection in people livi...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318196/ https://www.ncbi.nlm.nih.gov/pubmed/22536498 http://dx.doi.org/10.1155/2012/948059 |
_version_ | 1782228677269913600 |
---|---|
author | Maek-a-Nantawat, Wirach Avihingsanon, Anchalee Ohata, Pirapon June |
author_facet | Maek-a-Nantawat, Wirach Avihingsanon, Anchalee Ohata, Pirapon June |
author_sort | Maek-a-Nantawat, Wirach |
collection | PubMed |
description | Hepatitis B and C infections are prevalent among HIV-infected individuals with different epidemiologic profiles, modes of transmission, natural histories, and treatments. Southeast Asian countries are classified as “highly prevalent zones,” with a rate of hepatitis B and C coinfection in people living with HIV/AIDS of approximately 3.2–11%. Majority of hepatitis B coinfection is of genotype C. Most of the patients infected with hepatitis C in Thailand have genotype 3 which is significantly related to intravenous drug use whereas, in Vietnam, it is genotype 6. The options for antiretroviral drugs are limited and rely on global funds and research facilities. Only HBV treatment is available for free through the national health scheme. Screening tests for HBV and HCV prior to commencing antiretroviral treatment are low. Insufficient concern on hepatitis-virus-related liver malignancy and long-term hepatic morbidities is noted. Cost-effective HCV treatment can be incorporated into the national health program for those who need it by utilizing data obtained from clinical research studies. For example, patients infected with HCV genotype 2/3 with a certain IL-28B polymorphism can be treated with a shorter course of interferon and ribavirin which can also help reduce costs. |
format | Online Article Text |
id | pubmed-3318196 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33181962012-04-25 Challenges in Providing Treatment and Care for Viral Hepatitis among Individuals Co-Infected with HIV in Resource-Limited Settings Maek-a-Nantawat, Wirach Avihingsanon, Anchalee Ohata, Pirapon June AIDS Res Treat Review Article Hepatitis B and C infections are prevalent among HIV-infected individuals with different epidemiologic profiles, modes of transmission, natural histories, and treatments. Southeast Asian countries are classified as “highly prevalent zones,” with a rate of hepatitis B and C coinfection in people living with HIV/AIDS of approximately 3.2–11%. Majority of hepatitis B coinfection is of genotype C. Most of the patients infected with hepatitis C in Thailand have genotype 3 which is significantly related to intravenous drug use whereas, in Vietnam, it is genotype 6. The options for antiretroviral drugs are limited and rely on global funds and research facilities. Only HBV treatment is available for free through the national health scheme. Screening tests for HBV and HCV prior to commencing antiretroviral treatment are low. Insufficient concern on hepatitis-virus-related liver malignancy and long-term hepatic morbidities is noted. Cost-effective HCV treatment can be incorporated into the national health program for those who need it by utilizing data obtained from clinical research studies. For example, patients infected with HCV genotype 2/3 with a certain IL-28B polymorphism can be treated with a shorter course of interferon and ribavirin which can also help reduce costs. Hindawi Publishing Corporation 2012 2012-03-26 /pmc/articles/PMC3318196/ /pubmed/22536498 http://dx.doi.org/10.1155/2012/948059 Text en Copyright © 2012 Wirach Maek-a-Nantawat et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Maek-a-Nantawat, Wirach Avihingsanon, Anchalee Ohata, Pirapon June Challenges in Providing Treatment and Care for Viral Hepatitis among Individuals Co-Infected with HIV in Resource-Limited Settings |
title | Challenges in Providing Treatment and Care for Viral Hepatitis among Individuals Co-Infected with HIV in Resource-Limited Settings |
title_full | Challenges in Providing Treatment and Care for Viral Hepatitis among Individuals Co-Infected with HIV in Resource-Limited Settings |
title_fullStr | Challenges in Providing Treatment and Care for Viral Hepatitis among Individuals Co-Infected with HIV in Resource-Limited Settings |
title_full_unstemmed | Challenges in Providing Treatment and Care for Viral Hepatitis among Individuals Co-Infected with HIV in Resource-Limited Settings |
title_short | Challenges in Providing Treatment and Care for Viral Hepatitis among Individuals Co-Infected with HIV in Resource-Limited Settings |
title_sort | challenges in providing treatment and care for viral hepatitis among individuals co-infected with hiv in resource-limited settings |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318196/ https://www.ncbi.nlm.nih.gov/pubmed/22536498 http://dx.doi.org/10.1155/2012/948059 |
work_keys_str_mv | AT maekanantawatwirach challengesinprovidingtreatmentandcareforviralhepatitisamongindividualscoinfectedwithhivinresourcelimitedsettings AT avihingsanonanchalee challengesinprovidingtreatmentandcareforviralhepatitisamongindividualscoinfectedwithhivinresourcelimitedsettings AT ohatapiraponjune challengesinprovidingtreatmentandcareforviralhepatitisamongindividualscoinfectedwithhivinresourcelimitedsettings |