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Epigenetics and Autoimmune Diseases

Epigenetics is defined as the study of all inheritable and potentially reversible changes in genome function that do not alter the nucleotide sequence within the DNA. Epigenetic mechanisms such as DNA methylation, histone modification, nucleosome positioning, and microRNAs (miRNAs) are essential to...

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Detalles Bibliográficos
Autores principales: Quintero-Ronderos, Paula, Montoya-Ortiz, Gladis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318200/
https://www.ncbi.nlm.nih.gov/pubmed/22536485
http://dx.doi.org/10.1155/2012/593720
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author Quintero-Ronderos, Paula
Montoya-Ortiz, Gladis
author_facet Quintero-Ronderos, Paula
Montoya-Ortiz, Gladis
author_sort Quintero-Ronderos, Paula
collection PubMed
description Epigenetics is defined as the study of all inheritable and potentially reversible changes in genome function that do not alter the nucleotide sequence within the DNA. Epigenetic mechanisms such as DNA methylation, histone modification, nucleosome positioning, and microRNAs (miRNAs) are essential to carry out key functions in the regulation of gene expression. Therefore, the epigenetic mechanisms are a window to understanding the possible mechanisms involved in the pathogenesis of complex diseases such as autoimmune diseases. It is noteworthy that autoimmune diseases do not have the same epidemiology, pathology, or symptoms but do have a common origin that can be explained by the sharing of immunogenetic mechanisms. Currently, epigenetic research is looking for disruption in one or more epigenetic mechanisms to provide new insights into autoimmune diseases. The identification of cell-specific targets of epigenetic deregulation will serve us as clinical markers for diagnosis, disease progression, and therapy approaches.
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spelling pubmed-33182002012-04-25 Epigenetics and Autoimmune Diseases Quintero-Ronderos, Paula Montoya-Ortiz, Gladis Autoimmune Dis Review Article Epigenetics is defined as the study of all inheritable and potentially reversible changes in genome function that do not alter the nucleotide sequence within the DNA. Epigenetic mechanisms such as DNA methylation, histone modification, nucleosome positioning, and microRNAs (miRNAs) are essential to carry out key functions in the regulation of gene expression. Therefore, the epigenetic mechanisms are a window to understanding the possible mechanisms involved in the pathogenesis of complex diseases such as autoimmune diseases. It is noteworthy that autoimmune diseases do not have the same epidemiology, pathology, or symptoms but do have a common origin that can be explained by the sharing of immunogenetic mechanisms. Currently, epigenetic research is looking for disruption in one or more epigenetic mechanisms to provide new insights into autoimmune diseases. The identification of cell-specific targets of epigenetic deregulation will serve us as clinical markers for diagnosis, disease progression, and therapy approaches. Hindawi Publishing Corporation 2012 2012-03-22 /pmc/articles/PMC3318200/ /pubmed/22536485 http://dx.doi.org/10.1155/2012/593720 Text en Copyright © 2012 P. Quintero-Ronderos and G. Montoya-Ortiz. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Quintero-Ronderos, Paula
Montoya-Ortiz, Gladis
Epigenetics and Autoimmune Diseases
title Epigenetics and Autoimmune Diseases
title_full Epigenetics and Autoimmune Diseases
title_fullStr Epigenetics and Autoimmune Diseases
title_full_unstemmed Epigenetics and Autoimmune Diseases
title_short Epigenetics and Autoimmune Diseases
title_sort epigenetics and autoimmune diseases
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318200/
https://www.ncbi.nlm.nih.gov/pubmed/22536485
http://dx.doi.org/10.1155/2012/593720
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