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Carbon Monoxide Targeting Mitochondria
Mitochondria present two key roles on cellular functioning: (i) cell metabolism, being the main cellular source of energy and (ii) modulation of cell death, by mitochondrial membrane permeabilization. Carbon monoxide (CO) is an endogenously produced gaseoustransmitter, which presents several biologi...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318215/ https://www.ncbi.nlm.nih.gov/pubmed/22536507 http://dx.doi.org/10.1155/2012/749845 |
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author | Queiroga, Cláudia S. F. Almeida, Ana S. Vieira, Helena L. A. |
author_facet | Queiroga, Cláudia S. F. Almeida, Ana S. Vieira, Helena L. A. |
author_sort | Queiroga, Cláudia S. F. |
collection | PubMed |
description | Mitochondria present two key roles on cellular functioning: (i) cell metabolism, being the main cellular source of energy and (ii) modulation of cell death, by mitochondrial membrane permeabilization. Carbon monoxide (CO) is an endogenously produced gaseoustransmitter, which presents several biological functions and is involved in maintaining cell homeostasis and cytoprotection. Herein, mitochondrion is approached as the main cellular target of carbon monoxide (CO). In this paper, two main perspectives concerning CO modulation of mitochondrial functioning are evaluated. First, the role of CO on cellular metabolism, in particular oxidative phosphorylation, is discussed, namely, on: cytochrome c oxidase activity, mitochondrial respiration, oxygen consumption, mitochondrial biogenesis, and general cellular energetic status. Second, the mitochondrial pathways involved in cell death inhibition by CO are assessed, in particular the control of mitochondrial membrane permeabilization. |
format | Online Article Text |
id | pubmed-3318215 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-33182152012-04-25 Carbon Monoxide Targeting Mitochondria Queiroga, Cláudia S. F. Almeida, Ana S. Vieira, Helena L. A. Biochem Res Int Review Article Mitochondria present two key roles on cellular functioning: (i) cell metabolism, being the main cellular source of energy and (ii) modulation of cell death, by mitochondrial membrane permeabilization. Carbon monoxide (CO) is an endogenously produced gaseoustransmitter, which presents several biological functions and is involved in maintaining cell homeostasis and cytoprotection. Herein, mitochondrion is approached as the main cellular target of carbon monoxide (CO). In this paper, two main perspectives concerning CO modulation of mitochondrial functioning are evaluated. First, the role of CO on cellular metabolism, in particular oxidative phosphorylation, is discussed, namely, on: cytochrome c oxidase activity, mitochondrial respiration, oxygen consumption, mitochondrial biogenesis, and general cellular energetic status. Second, the mitochondrial pathways involved in cell death inhibition by CO are assessed, in particular the control of mitochondrial membrane permeabilization. Hindawi Publishing Corporation 2012 2012-03-20 /pmc/articles/PMC3318215/ /pubmed/22536507 http://dx.doi.org/10.1155/2012/749845 Text en Copyright © 2012 Cláudia S. F. Queiroga et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Queiroga, Cláudia S. F. Almeida, Ana S. Vieira, Helena L. A. Carbon Monoxide Targeting Mitochondria |
title | Carbon Monoxide Targeting Mitochondria |
title_full | Carbon Monoxide Targeting Mitochondria |
title_fullStr | Carbon Monoxide Targeting Mitochondria |
title_full_unstemmed | Carbon Monoxide Targeting Mitochondria |
title_short | Carbon Monoxide Targeting Mitochondria |
title_sort | carbon monoxide targeting mitochondria |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318215/ https://www.ncbi.nlm.nih.gov/pubmed/22536507 http://dx.doi.org/10.1155/2012/749845 |
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