The Stochastic Evolution of a Protocell: The Gillespie Algorithm in a Dynamically Varying Volume

We propose an improvement of the Gillespie algorithm allowing us to study the time evolution of an ensemble of chemical reactions occurring in a varying volume, whose growth is directly related to the amount of some specific molecules, belonging to the reactions set. This allows us to study the stoc...

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Detalles Bibliográficos
Autores principales: Carletti, T., Filisetti, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318221/
https://www.ncbi.nlm.nih.gov/pubmed/22536297
http://dx.doi.org/10.1155/2012/423627
Descripción
Sumario:We propose an improvement of the Gillespie algorithm allowing us to study the time evolution of an ensemble of chemical reactions occurring in a varying volume, whose growth is directly related to the amount of some specific molecules, belonging to the reactions set. This allows us to study the stochastic evolution of a protocell, whose volume increases because of the production of container molecules. Several protocell models are considered and compared with the deterministic models.

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