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Cassia tora Linn Cream Inhibits Ultraviolet-B-Induced Psoriasis in Rats

The aim of present study was to determine the antipsoriatic activity of newly formulated O/W creams of methanolic extract of Cassia tora L. leaves by using ultraviolet-B-induced psoriasis in rat. The plant Cassia tora L. is traditionally claimed to be useful in the treatment of a number of skin dise...

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Autores principales: Singhal, Manmohan, Kansara, Niraj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scholarly Research Network 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318897/
https://www.ncbi.nlm.nih.gov/pubmed/22536527
http://dx.doi.org/10.5402/2012/346510
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author Singhal, Manmohan
Kansara, Niraj
author_facet Singhal, Manmohan
Kansara, Niraj
author_sort Singhal, Manmohan
collection PubMed
description The aim of present study was to determine the antipsoriatic activity of newly formulated O/W creams of methanolic extract of Cassia tora L. leaves by using ultraviolet-B-induced psoriasis in rat. The plant Cassia tora L. is traditionally claimed to be useful in the treatment of a number of skin diseases. However, there are no established scientific reports for its antipsoriatic activity. Methanolic Cassia tora L. leaves extract was used to prepare various concentrations of O/W creams and tested for acute dermal toxicity study. The different O/W creams showed good physical characteristics and passed the sensitivity, irritation, grittiness and bleeding test. The results of acute dermal toxicity showed that the creams were safe up to the dose of 2000 mg/kg. In case of psoriasis model, histopathological analysis revealed that there were absence of Munro's microabscess, elongation of rete ridges, and capillary loop dilation in the section in Test 2 (0.1%) and standard group. O/W creams and methanolic extract of Cassia tora L. leaves exhibited significant reduction in percentage of relative epidermal thickness and spleen index as compared to positive control. We concluded that topical O/W creams and crude extract containing methanolic extract of Cassia tora L. leaves have potent antipsoriatic activity in ultraviolet-B-induced psoriasis in rat.
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spelling pubmed-33188972012-04-25 Cassia tora Linn Cream Inhibits Ultraviolet-B-Induced Psoriasis in Rats Singhal, Manmohan Kansara, Niraj ISRN Dermatol Research Article The aim of present study was to determine the antipsoriatic activity of newly formulated O/W creams of methanolic extract of Cassia tora L. leaves by using ultraviolet-B-induced psoriasis in rat. The plant Cassia tora L. is traditionally claimed to be useful in the treatment of a number of skin diseases. However, there are no established scientific reports for its antipsoriatic activity. Methanolic Cassia tora L. leaves extract was used to prepare various concentrations of O/W creams and tested for acute dermal toxicity study. The different O/W creams showed good physical characteristics and passed the sensitivity, irritation, grittiness and bleeding test. The results of acute dermal toxicity showed that the creams were safe up to the dose of 2000 mg/kg. In case of psoriasis model, histopathological analysis revealed that there were absence of Munro's microabscess, elongation of rete ridges, and capillary loop dilation in the section in Test 2 (0.1%) and standard group. O/W creams and methanolic extract of Cassia tora L. leaves exhibited significant reduction in percentage of relative epidermal thickness and spleen index as compared to positive control. We concluded that topical O/W creams and crude extract containing methanolic extract of Cassia tora L. leaves have potent antipsoriatic activity in ultraviolet-B-induced psoriasis in rat. International Scholarly Research Network 2012-03-25 /pmc/articles/PMC3318897/ /pubmed/22536527 http://dx.doi.org/10.5402/2012/346510 Text en Copyright © 2012 M. Singhal and N. Kansara. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Singhal, Manmohan
Kansara, Niraj
Cassia tora Linn Cream Inhibits Ultraviolet-B-Induced Psoriasis in Rats
title Cassia tora Linn Cream Inhibits Ultraviolet-B-Induced Psoriasis in Rats
title_full Cassia tora Linn Cream Inhibits Ultraviolet-B-Induced Psoriasis in Rats
title_fullStr Cassia tora Linn Cream Inhibits Ultraviolet-B-Induced Psoriasis in Rats
title_full_unstemmed Cassia tora Linn Cream Inhibits Ultraviolet-B-Induced Psoriasis in Rats
title_short Cassia tora Linn Cream Inhibits Ultraviolet-B-Induced Psoriasis in Rats
title_sort cassia tora linn cream inhibits ultraviolet-b-induced psoriasis in rats
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318897/
https://www.ncbi.nlm.nih.gov/pubmed/22536527
http://dx.doi.org/10.5402/2012/346510
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