Cargando…
Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates.
Several known trans-splicing RNA structures were used to define a canonical trans-splicing structure which was then used to perform a computer search of the EMBL nucleotide database. In addition to most known trans-splicing structures, many putative new trans-splicing sites were detected. These were...
Autores principales: | , |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
1990
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC331928/ https://www.ncbi.nlm.nih.gov/pubmed/2395638 |
_version_ | 1782121204670267392 |
---|---|
author | Dandekar, T Sibbald, P R |
author_facet | Dandekar, T Sibbald, P R |
author_sort | Dandekar, T |
collection | PubMed |
description | Several known trans-splicing RNA structures were used to define a canonical trans-splicing structure which was then used to perform a computer search of the EMBL nucleotide database. In addition to most known trans-splicing structures, many putative new trans-splicing sites were detected. These were found in a broad range of organisms including the vertebrates. Control experiments indicate that the search predicts known false positives at a rate of only 20%. Trans-splicing may therefore be a very wide-spread phenomenon. |
format | Text |
id | pubmed-331928 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1990 |
record_format | MEDLINE/PubMed |
spelling | pubmed-3319282004-02-10 Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates. Dandekar, T Sibbald, P R Nucleic Acids Res Several known trans-splicing RNA structures were used to define a canonical trans-splicing structure which was then used to perform a computer search of the EMBL nucleotide database. In addition to most known trans-splicing structures, many putative new trans-splicing sites were detected. These were found in a broad range of organisms including the vertebrates. Control experiments indicate that the search predicts known false positives at a rate of only 20%. Trans-splicing may therefore be a very wide-spread phenomenon. 1990-08-25 /pmc/articles/PMC331928/ /pubmed/2395638 Text en |
spellingShingle | Dandekar, T Sibbald, P R Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates. |
title | Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates. |
title_full | Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates. |
title_fullStr | Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates. |
title_full_unstemmed | Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates. |
title_short | Trans-splicing of pre-mRNA is predicted to occur in a wide range of organisms including vertebrates. |
title_sort | trans-splicing of pre-mrna is predicted to occur in a wide range of organisms including vertebrates. |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC331928/ https://www.ncbi.nlm.nih.gov/pubmed/2395638 |
work_keys_str_mv | AT dandekart transsplicingofpremrnaispredictedtooccurinawiderangeoforganismsincludingvertebrates AT sibbaldpr transsplicingofpremrnaispredictedtooccurinawiderangeoforganismsincludingvertebrates |