The mechanism of OTUB1 inhibition of ubiquitination

Histones are ubiquitinated in response to DNA double strand breaks (DSB), promoting recruitment of repair proteins to chromatin(1). UBC13 (UBE2N) is an ubiquitin conjugating enzyme (E2) that heterodimerizes with UEV1a(2) and synthesizes K63–linked polyubiquitin (K63Ub) chains at DSB sites in concert...

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Detalles Bibliográficos
Autores principales: Wiener, Reuven, Zhang, Xiangbin, Wang, Tao, Wolberger, Cynthia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319311/
https://www.ncbi.nlm.nih.gov/pubmed/22367539
http://dx.doi.org/10.1038/nature10911

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319311/
https://www.ncbi.nlm.nih.gov/pubmed/22367539
http://dx.doi.org/10.1038/nature10911

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