Cargando…
Dichotomy in the definition of prescriptive information suggests both prescribed data and prescribed algorithms: biosemiotics applications in genomic systems
The fields of molecular biology and computer science have cooperated over recent years to create a synergy between the cybernetic and biosemiotic relationship found in cellular genomics to that of information and language found in computational systems. Biological information frequently manifests it...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319427/ https://www.ncbi.nlm.nih.gov/pubmed/22413926 http://dx.doi.org/10.1186/1742-4682-9-8 |
_version_ | 1782228720864460800 |
---|---|
author | D'Onofrio, David J Abel, David L Johnson, Donald E |
author_facet | D'Onofrio, David J Abel, David L Johnson, Donald E |
author_sort | D'Onofrio, David J |
collection | PubMed |
description | The fields of molecular biology and computer science have cooperated over recent years to create a synergy between the cybernetic and biosemiotic relationship found in cellular genomics to that of information and language found in computational systems. Biological information frequently manifests its "meaning" through instruction or actual production of formal bio-function. Such information is called Prescriptive Information (PI). PI programs organize and execute a prescribed set of choices. Closer examination of this term in cellular systems has led to a dichotomy in its definition suggesting both prescribed data and prescribed algorithms are constituents of PI. This paper looks at this dichotomy as expressed in both the genetic code and in the central dogma of protein synthesis. An example of a genetic algorithm is modeled after the ribosome, and an examination of the protein synthesis process is used to differentiate PI data from PI algorithms. |
format | Online Article Text |
id | pubmed-3319427 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-33194272012-04-10 Dichotomy in the definition of prescriptive information suggests both prescribed data and prescribed algorithms: biosemiotics applications in genomic systems D'Onofrio, David J Abel, David L Johnson, Donald E Theor Biol Med Model Review The fields of molecular biology and computer science have cooperated over recent years to create a synergy between the cybernetic and biosemiotic relationship found in cellular genomics to that of information and language found in computational systems. Biological information frequently manifests its "meaning" through instruction or actual production of formal bio-function. Such information is called Prescriptive Information (PI). PI programs organize and execute a prescribed set of choices. Closer examination of this term in cellular systems has led to a dichotomy in its definition suggesting both prescribed data and prescribed algorithms are constituents of PI. This paper looks at this dichotomy as expressed in both the genetic code and in the central dogma of protein synthesis. An example of a genetic algorithm is modeled after the ribosome, and an examination of the protein synthesis process is used to differentiate PI data from PI algorithms. BioMed Central 2012-03-14 /pmc/articles/PMC3319427/ /pubmed/22413926 http://dx.doi.org/10.1186/1742-4682-9-8 Text en Copyright ©2012 D'Onofrio et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review D'Onofrio, David J Abel, David L Johnson, Donald E Dichotomy in the definition of prescriptive information suggests both prescribed data and prescribed algorithms: biosemiotics applications in genomic systems |
title | Dichotomy in the definition of prescriptive information suggests both prescribed data and prescribed algorithms: biosemiotics applications in genomic systems |
title_full | Dichotomy in the definition of prescriptive information suggests both prescribed data and prescribed algorithms: biosemiotics applications in genomic systems |
title_fullStr | Dichotomy in the definition of prescriptive information suggests both prescribed data and prescribed algorithms: biosemiotics applications in genomic systems |
title_full_unstemmed | Dichotomy in the definition of prescriptive information suggests both prescribed data and prescribed algorithms: biosemiotics applications in genomic systems |
title_short | Dichotomy in the definition of prescriptive information suggests both prescribed data and prescribed algorithms: biosemiotics applications in genomic systems |
title_sort | dichotomy in the definition of prescriptive information suggests both prescribed data and prescribed algorithms: biosemiotics applications in genomic systems |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319427/ https://www.ncbi.nlm.nih.gov/pubmed/22413926 http://dx.doi.org/10.1186/1742-4682-9-8 |
work_keys_str_mv | AT donofriodavidj dichotomyinthedefinitionofprescriptiveinformationsuggestsbothprescribeddataandprescribedalgorithmsbiosemioticsapplicationsingenomicsystems AT abeldavidl dichotomyinthedefinitionofprescriptiveinformationsuggestsbothprescribeddataandprescribedalgorithmsbiosemioticsapplicationsingenomicsystems AT johnsondonalde dichotomyinthedefinitionofprescriptiveinformationsuggestsbothprescribeddataandprescribedalgorithmsbiosemioticsapplicationsingenomicsystems |