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Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes

BACKGROUND: We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hyp...

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Autores principales: Misu, Hirofumi, Ishikura, Kazuhide, Kurita, Seiichiro, Takeshita, Yumie, Ota, Tsuguhito, Saito, Yoshiro, Takahashi, Kazuhiko, Kaneko, Shuichi, Takamura, Toshinari
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319626/
https://www.ncbi.nlm.nih.gov/pubmed/22496878
http://dx.doi.org/10.1371/journal.pone.0034952
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author Misu, Hirofumi
Ishikura, Kazuhide
Kurita, Seiichiro
Takeshita, Yumie
Ota, Tsuguhito
Saito, Yoshiro
Takahashi, Kazuhiko
Kaneko, Shuichi
Takamura, Toshinari
author_facet Misu, Hirofumi
Ishikura, Kazuhide
Kurita, Seiichiro
Takeshita, Yumie
Ota, Tsuguhito
Saito, Yoshiro
Takahashi, Kazuhiko
Kaneko, Shuichi
Takamura, Toshinari
author_sort Misu, Hirofumi
collection PubMed
description BACKGROUND: We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hypoadiponectinemia in patients with type 2 diabetes. METHODOLOGY/PRINCIPAL FINDINGS: We compared serum levels of SeP with those of adiponectin and other clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = −0.355, P = 0.034; r = −0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = −0.343, P = 0.022; β = −0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet. CONCLUSIONS/SIGNIFICANCE: These results suggest that overproduction of liver-derived secretory protein SeP is connected with hypoadiponectinemia in patients with type 2 diabetes.
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spelling pubmed-33196262012-04-11 Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes Misu, Hirofumi Ishikura, Kazuhide Kurita, Seiichiro Takeshita, Yumie Ota, Tsuguhito Saito, Yoshiro Takahashi, Kazuhiko Kaneko, Shuichi Takamura, Toshinari PLoS One Research Article BACKGROUND: We recently identified selenoprotein P (SeP) as a liver-derived secretory protein that causes insulin resistance in the liver and skeletal muscle; however, it is unknown whether and, if so, how SeP acts on adipose tissue. The present study tested the hypothesis that SeP is related to hypoadiponectinemia in patients with type 2 diabetes. METHODOLOGY/PRINCIPAL FINDINGS: We compared serum levels of SeP with those of adiponectin and other clinical parameters in 36 patients with type 2 diabetes. We also measured levels of blood adiponectin in SeP knockout mice. Circulating SeP levels were positively correlated with fasting plasma glucose (r = 0.35, P = 0.037) and negatively associated with both total and high-molecular adiponectin in patients with type 2 diabetes (r = −0.355, P = 0.034; r = −0.367, P = 0.028). SeP was a predictor of both total and high-molecular adiponectin, independently of age, body weight, and quantitative insulin sensitivity index (β = −0.343, P = 0.022; β = −0.357, P = 0.017). SeP knockout mice exhibited an increase in blood adiponectin levels when fed regular chow or a high sucrose, high fat diet. CONCLUSIONS/SIGNIFICANCE: These results suggest that overproduction of liver-derived secretory protein SeP is connected with hypoadiponectinemia in patients with type 2 diabetes. Public Library of Science 2012-04-04 /pmc/articles/PMC3319626/ /pubmed/22496878 http://dx.doi.org/10.1371/journal.pone.0034952 Text en Misu et al. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Misu, Hirofumi
Ishikura, Kazuhide
Kurita, Seiichiro
Takeshita, Yumie
Ota, Tsuguhito
Saito, Yoshiro
Takahashi, Kazuhiko
Kaneko, Shuichi
Takamura, Toshinari
Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes
title Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes
title_full Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes
title_fullStr Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes
title_full_unstemmed Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes
title_short Inverse Correlation between Serum Levels of Selenoprotein P and Adiponectin in Patients with Type 2 Diabetes
title_sort inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3319626/
https://www.ncbi.nlm.nih.gov/pubmed/22496878
http://dx.doi.org/10.1371/journal.pone.0034952
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