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Nongenomic Mechanisms of PTEN Regulation

A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cel...

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Detalles Bibliográficos
Autores principales: Fata, Jimmie E., Debnath, Shawon, Jenkins, Edmund C., Fournier, Marcia V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320059/
https://www.ncbi.nlm.nih.gov/pubmed/22536248
http://dx.doi.org/10.1155/2012/379685
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author Fata, Jimmie E.
Debnath, Shawon
Jenkins, Edmund C.
Fournier, Marcia V.
author_facet Fata, Jimmie E.
Debnath, Shawon
Jenkins, Edmund C.
Fournier, Marcia V.
author_sort Fata, Jimmie E.
collection PubMed
description A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregulation of these mechanisms can alter cellular processes and tissue architecture and ultimately lead to oncogenic transformation. Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events.
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spelling pubmed-33200592012-04-25 Nongenomic Mechanisms of PTEN Regulation Fata, Jimmie E. Debnath, Shawon Jenkins, Edmund C. Fournier, Marcia V. Int J Cell Biol Review Article A large amount of data supports the view that PTEN is a bona fide tumor suppressor gene. However, recent evidence suggests that derailment of cellular localization and expression levels of functional nonmutated PTEN is a determining force in inducing abnormal cellular and tissue outcomes. As the cellular mechanisms that regulate normal PTEN enzymatic activity resolve, it is evident that deregulation of these mechanisms can alter cellular processes and tissue architecture and ultimately lead to oncogenic transformation. Here we discuss PTEN ubiquitination, PTEN complex formation with components of the adherens junction, PTEN nuclear localization, and microRNA regulation of PTEN as essential regulatory mechanisms that determine PTEN function independent of gene mutations and epigenetic events. Hindawi Publishing Corporation 2012 2012-03-25 /pmc/articles/PMC3320059/ /pubmed/22536248 http://dx.doi.org/10.1155/2012/379685 Text en Copyright © 2012 Jimmie E. Fata et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Fata, Jimmie E.
Debnath, Shawon
Jenkins, Edmund C.
Fournier, Marcia V.
Nongenomic Mechanisms of PTEN Regulation
title Nongenomic Mechanisms of PTEN Regulation
title_full Nongenomic Mechanisms of PTEN Regulation
title_fullStr Nongenomic Mechanisms of PTEN Regulation
title_full_unstemmed Nongenomic Mechanisms of PTEN Regulation
title_short Nongenomic Mechanisms of PTEN Regulation
title_sort nongenomic mechanisms of pten regulation
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320059/
https://www.ncbi.nlm.nih.gov/pubmed/22536248
http://dx.doi.org/10.1155/2012/379685
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