Molecular Mechanisms of West Nile Virus Pathogenesis in Brain Cells

We analyzed the response of human glioma cells to West Nile virus infection by investigating host transcriptional changes. Changes in expression of 23 genes showed similarities to those in other neurodegenerative diseases. These changes may be useful as potential biomarkers and elucidate novel mecha...

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Detalles Bibliográficos
Autores principales: Koh, Wee-Lee, Ng, Mah-Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2005
Materias:
Dispatch
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320339/
https://www.ncbi.nlm.nih.gov/pubmed/15829208
http://dx.doi.org/10.3201/eid1104.041076
Descripción
Sumario:We analyzed the response of human glioma cells to West Nile virus infection by investigating host transcriptional changes. Changes in expression of 23 genes showed similarities to those in other neurodegenerative diseases. These changes may be useful as potential biomarkers and elucidate novel mechanisms behind the neuropathology of infection with this virus.

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