Human Coronavirus NL63, France

The human coronavirus NL63 (HCoV-NL63) was first identified in the Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory...

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Autores principales: Vabret, Astrid, Mourez, Thomas, Dina, Julia, van der Hoek, Lia, Gouarin, Stéphanie, Petitjean, Joëlle, Brouard, Jacques, Freymuth, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2005
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320486/
https://www.ncbi.nlm.nih.gov/pubmed/16102311
http://dx.doi.org/10.3201/eid1108.050110
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author Vabret, Astrid
Mourez, Thomas
Dina, Julia
van der Hoek, Lia
Gouarin, Stéphanie
Petitjean, Joëlle
Brouard, Jacques
Freymuth, François
author_facet Vabret, Astrid
Mourez, Thomas
Dina, Julia
van der Hoek, Lia
Gouarin, Stéphanie
Petitjean, Joëlle
Brouard, Jacques
Freymuth, François
author_sort Vabret, Astrid
collection PubMed
description The human coronavirus NL63 (HCoV-NL63) was first identified in the Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. The highest prevalence was found in February (18%). The main symptoms were fever (61%), rhinitis (39%), bronchiolitis (39%), digestive problems (33%), otitis (28%), pharyngitis (22%), and conjunctivitis (17%). A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. Phylogenetic analysis indicated that strains with different genetic markers cocirculate in France.
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spelling pubmed-33204862012-04-11 Human Coronavirus NL63, France Vabret, Astrid Mourez, Thomas Dina, Julia van der Hoek, Lia Gouarin, Stéphanie Petitjean, Joëlle Brouard, Jacques Freymuth, François Emerg Infect Dis Research The human coronavirus NL63 (HCoV-NL63) was first identified in the Netherlands, and its circulation in France has not been investigated. We studied HCoV-NL63 infection in hospitalized children diagnosed with respiratory tract infections. From November 2002 to April 2003, we evaluated 300 respiratory specimens for HCoV-NL63. Of the 300 samples, 28 (9.3%) were positive for HCoV-NL63. The highest prevalence was found in February (18%). The main symptoms were fever (61%), rhinitis (39%), bronchiolitis (39%), digestive problems (33%), otitis (28%), pharyngitis (22%), and conjunctivitis (17%). A fragment of the spike protein gene was sequenced to determine the variety of circulating HCoV-NL63. Phylogenetic analysis indicated that strains with different genetic markers cocirculate in France. Centers for Disease Control and Prevention 2005-08 /pmc/articles/PMC3320486/ /pubmed/16102311 http://dx.doi.org/10.3201/eid1108.050110 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Vabret, Astrid
Mourez, Thomas
Dina, Julia
van der Hoek, Lia
Gouarin, Stéphanie
Petitjean, Joëlle
Brouard, Jacques
Freymuth, François
Human Coronavirus NL63, France
title Human Coronavirus NL63, France
title_full Human Coronavirus NL63, France
title_fullStr Human Coronavirus NL63, France
title_full_unstemmed Human Coronavirus NL63, France
title_short Human Coronavirus NL63, France
title_sort human coronavirus nl63, france
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320486/
https://www.ncbi.nlm.nih.gov/pubmed/16102311
http://dx.doi.org/10.3201/eid1108.050110
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