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Influenza A (H3N2) Outbreak, Nepal
In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal. Hemagglutination inhibition showed that ≈40% of the viruses from this outbreak were antigenically distinct from the A/Wyoming/3/03 vaccine strain. Four amino acid differences were observe...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Centers for Disease Control and Prevention
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320503/ https://www.ncbi.nlm.nih.gov/pubmed/16102305 http://dx.doi.org/10.3201/eid1108.050302 |
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author | Daum, Luke T. Shaw, Michael W. Klimov, Alexander I. Canas, Linda C. Macias, Elizabeth A. Niemeyer, Debra Chambers, James P. Renthal, Robert Shrestha, Sanjaya K. Acharya, Ramesh P. Huzdar, Shankar P. Rimal, Nirmal Myint, Khin S. Gould, Philip |
author_facet | Daum, Luke T. Shaw, Michael W. Klimov, Alexander I. Canas, Linda C. Macias, Elizabeth A. Niemeyer, Debra Chambers, James P. Renthal, Robert Shrestha, Sanjaya K. Acharya, Ramesh P. Huzdar, Shankar P. Rimal, Nirmal Myint, Khin S. Gould, Philip |
author_sort | Daum, Luke T. |
collection | PubMed |
description | In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal. Hemagglutination inhibition showed that ≈40% of the viruses from this outbreak were antigenically distinct from the A/Wyoming/3/03 vaccine strain. Four amino acid differences were observed in most of the 26 isolates compared with the A/Wyoming/3/2003 vaccine strain. All 4 substitutions are located within or adjacent to known antibody-binding sites. Several isolates showed a lysine-to-asparagine substitution at position 145 (K145N) in the hemagglutinin molecule, which may be noteworthy since position 145 is located within a glycosylation site and adjacent to an antibody-binding site. H3N2 viruses continue to drift from the vaccine strain and may remain as the dominant strains during the 2005–2006 influenza season. Thus, the 2005–2006 Northern Hemisphere vaccine strain was changed to A/California/7/2004, a virus with all 4 amino acid substitutions observed in these Nepalese isolates. |
format | Online Article Text |
id | pubmed-3320503 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Centers for Disease Control and Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-33205032012-04-11 Influenza A (H3N2) Outbreak, Nepal Daum, Luke T. Shaw, Michael W. Klimov, Alexander I. Canas, Linda C. Macias, Elizabeth A. Niemeyer, Debra Chambers, James P. Renthal, Robert Shrestha, Sanjaya K. Acharya, Ramesh P. Huzdar, Shankar P. Rimal, Nirmal Myint, Khin S. Gould, Philip Emerg Infect Dis Research In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal. Hemagglutination inhibition showed that ≈40% of the viruses from this outbreak were antigenically distinct from the A/Wyoming/3/03 vaccine strain. Four amino acid differences were observed in most of the 26 isolates compared with the A/Wyoming/3/2003 vaccine strain. All 4 substitutions are located within or adjacent to known antibody-binding sites. Several isolates showed a lysine-to-asparagine substitution at position 145 (K145N) in the hemagglutinin molecule, which may be noteworthy since position 145 is located within a glycosylation site and adjacent to an antibody-binding site. H3N2 viruses continue to drift from the vaccine strain and may remain as the dominant strains during the 2005–2006 influenza season. Thus, the 2005–2006 Northern Hemisphere vaccine strain was changed to A/California/7/2004, a virus with all 4 amino acid substitutions observed in these Nepalese isolates. Centers for Disease Control and Prevention 2005-08 /pmc/articles/PMC3320503/ /pubmed/16102305 http://dx.doi.org/10.3201/eid1108.050302 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited. |
spellingShingle | Research Daum, Luke T. Shaw, Michael W. Klimov, Alexander I. Canas, Linda C. Macias, Elizabeth A. Niemeyer, Debra Chambers, James P. Renthal, Robert Shrestha, Sanjaya K. Acharya, Ramesh P. Huzdar, Shankar P. Rimal, Nirmal Myint, Khin S. Gould, Philip Influenza A (H3N2) Outbreak, Nepal |
title | Influenza A (H3N2) Outbreak, Nepal |
title_full | Influenza A (H3N2) Outbreak, Nepal |
title_fullStr | Influenza A (H3N2) Outbreak, Nepal |
title_full_unstemmed | Influenza A (H3N2) Outbreak, Nepal |
title_short | Influenza A (H3N2) Outbreak, Nepal |
title_sort | influenza a (h3n2) outbreak, nepal |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320503/ https://www.ncbi.nlm.nih.gov/pubmed/16102305 http://dx.doi.org/10.3201/eid1108.050302 |
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