Cargando…

Influenza A (H3N2) Outbreak, Nepal

In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal. Hemagglutination inhibition showed that ≈40% of the viruses from this outbreak were antigenically distinct from the A/Wyoming/3/03 vaccine strain. Four amino acid differences were observe...

Descripción completa

Detalles Bibliográficos
Autores principales: Daum, Luke T., Shaw, Michael W., Klimov, Alexander I., Canas, Linda C., Macias, Elizabeth A., Niemeyer, Debra, Chambers, James P., Renthal, Robert, Shrestha, Sanjaya K., Acharya, Ramesh P., Huzdar, Shankar P., Rimal, Nirmal, Myint, Khin S., Gould, Philip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320503/
https://www.ncbi.nlm.nih.gov/pubmed/16102305
http://dx.doi.org/10.3201/eid1108.050302
_version_ 1782228845810679808
author Daum, Luke T.
Shaw, Michael W.
Klimov, Alexander I.
Canas, Linda C.
Macias, Elizabeth A.
Niemeyer, Debra
Chambers, James P.
Renthal, Robert
Shrestha, Sanjaya K.
Acharya, Ramesh P.
Huzdar, Shankar P.
Rimal, Nirmal
Myint, Khin S.
Gould, Philip
author_facet Daum, Luke T.
Shaw, Michael W.
Klimov, Alexander I.
Canas, Linda C.
Macias, Elizabeth A.
Niemeyer, Debra
Chambers, James P.
Renthal, Robert
Shrestha, Sanjaya K.
Acharya, Ramesh P.
Huzdar, Shankar P.
Rimal, Nirmal
Myint, Khin S.
Gould, Philip
author_sort Daum, Luke T.
collection PubMed
description In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal. Hemagglutination inhibition showed that ≈40% of the viruses from this outbreak were antigenically distinct from the A/Wyoming/3/03 vaccine strain. Four amino acid differences were observed in most of the 26 isolates compared with the A/Wyoming/3/2003 vaccine strain. All 4 substitutions are located within or adjacent to known antibody-binding sites. Several isolates showed a lysine-to-asparagine substitution at position 145 (K145N) in the hemagglutinin molecule, which may be noteworthy since position 145 is located within a glycosylation site and adjacent to an antibody-binding site. H3N2 viruses continue to drift from the vaccine strain and may remain as the dominant strains during the 2005–2006 influenza season. Thus, the 2005–2006 Northern Hemisphere vaccine strain was changed to A/California/7/2004, a virus with all 4 amino acid substitutions observed in these Nepalese isolates.
format Online
Article
Text
id pubmed-3320503
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Centers for Disease Control and Prevention
record_format MEDLINE/PubMed
spelling pubmed-33205032012-04-11 Influenza A (H3N2) Outbreak, Nepal Daum, Luke T. Shaw, Michael W. Klimov, Alexander I. Canas, Linda C. Macias, Elizabeth A. Niemeyer, Debra Chambers, James P. Renthal, Robert Shrestha, Sanjaya K. Acharya, Ramesh P. Huzdar, Shankar P. Rimal, Nirmal Myint, Khin S. Gould, Philip Emerg Infect Dis Research In July 2004, an outbreak of influenza A (H3N2) was detected at 3 Bhutanese refugee camps in southeastern Nepal. Hemagglutination inhibition showed that ≈40% of the viruses from this outbreak were antigenically distinct from the A/Wyoming/3/03 vaccine strain. Four amino acid differences were observed in most of the 26 isolates compared with the A/Wyoming/3/2003 vaccine strain. All 4 substitutions are located within or adjacent to known antibody-binding sites. Several isolates showed a lysine-to-asparagine substitution at position 145 (K145N) in the hemagglutinin molecule, which may be noteworthy since position 145 is located within a glycosylation site and adjacent to an antibody-binding site. H3N2 viruses continue to drift from the vaccine strain and may remain as the dominant strains during the 2005–2006 influenza season. Thus, the 2005–2006 Northern Hemisphere vaccine strain was changed to A/California/7/2004, a virus with all 4 amino acid substitutions observed in these Nepalese isolates. Centers for Disease Control and Prevention 2005-08 /pmc/articles/PMC3320503/ /pubmed/16102305 http://dx.doi.org/10.3201/eid1108.050302 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research
Daum, Luke T.
Shaw, Michael W.
Klimov, Alexander I.
Canas, Linda C.
Macias, Elizabeth A.
Niemeyer, Debra
Chambers, James P.
Renthal, Robert
Shrestha, Sanjaya K.
Acharya, Ramesh P.
Huzdar, Shankar P.
Rimal, Nirmal
Myint, Khin S.
Gould, Philip
Influenza A (H3N2) Outbreak, Nepal
title Influenza A (H3N2) Outbreak, Nepal
title_full Influenza A (H3N2) Outbreak, Nepal
title_fullStr Influenza A (H3N2) Outbreak, Nepal
title_full_unstemmed Influenza A (H3N2) Outbreak, Nepal
title_short Influenza A (H3N2) Outbreak, Nepal
title_sort influenza a (h3n2) outbreak, nepal
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3320503/
https://www.ncbi.nlm.nih.gov/pubmed/16102305
http://dx.doi.org/10.3201/eid1108.050302
work_keys_str_mv AT daumluket influenzaah3n2outbreaknepal
AT shawmichaelw influenzaah3n2outbreaknepal
AT klimovalexanderi influenzaah3n2outbreaknepal
AT canaslindac influenzaah3n2outbreaknepal
AT maciaselizabetha influenzaah3n2outbreaknepal
AT niemeyerdebra influenzaah3n2outbreaknepal
AT chambersjamesp influenzaah3n2outbreaknepal
AT renthalrobert influenzaah3n2outbreaknepal
AT shresthasanjayak influenzaah3n2outbreaknepal
AT acharyarameshp influenzaah3n2outbreaknepal
AT huzdarshankarp influenzaah3n2outbreaknepal
AT rimalnirmal influenzaah3n2outbreaknepal
AT myintkhins influenzaah3n2outbreaknepal
AT gouldphilip influenzaah3n2outbreaknepal